Tyrosine-protein phosphatase non-receptor type 22
Intramolecular
Cysteine 129 and cysteine 227
Cysteine 129 and cysteine 139
Cysteine 227 and cysteine 231
Cysteine 139 and cysteine 227
Cysteine 227 and cysteine 238
Cysteine 231 and cysteine 238
Cysteine 224 and cysteine 238
2qcj B 129 B 227
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 22 between cysteines 129 and 227.
Details
Redox score ?
69
PDB code
2qcj
Structure name
native structure of lyp
Structure deposition date
2007-06-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
6
% buried
100
Peptide accession
Q9Y2R2
Residue number A
129
Residue number B
227
Peptide name
Tyrosine-protein phosphatase non-receptor type 22
Ligandability
Cysteine 129 of Tyrosine-protein phosphatase non-receptor type 22
Cysteine 227 of Tyrosine-protein phosphatase non-receptor type 22
3olr D 129 D 139
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 22 between cysteines 129 and 139.
Details
Redox score ?
65
PDB code
3olr
Structure name
ptpn22 in complex with consensus phospho-tyrosine peptide 1
Structure deposition date
2010-08-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
100
Peptide accession
Q9Y2R2
Residue number A
129
Residue number B
139
Peptide name
Tyrosine-protein phosphatase non-receptor type 22
Ligandability
Cysteine 129 of Tyrosine-protein phosphatase non-receptor type 22
Cysteine 139 of Tyrosine-protein phosphatase non-receptor type 22
2qcj A 227 A 231
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 22 between cysteines 227 and 231.
Details
Redox score ?
61
PDB code
2qcj
Structure name
native structure of lyp
Structure deposition date
2007-06-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
93
Minimum pKa ?
5
% buried
99
Peptide accession
Q9Y2R2
Residue number A
227
Residue number B
231
Peptide name
Tyrosine-protein phosphatase non-receptor type 22
Ligandability
Cysteine 227 of Tyrosine-protein phosphatase non-receptor type 22
Cysteine 231 of Tyrosine-protein phosphatase non-receptor type 22
2qct A 139 A 227
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 22 between cysteines 139 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
2qct
Structure name
structure of lyp with inhibitor i-c11
Structure deposition date
2007-06-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
100
Peptide accession
Q9Y2R2
Residue number A
139
Residue number B
227
Peptide name
Tyrosine-protein phosphatase non-receptor type 22
Ligandability
Cysteine 139 of Tyrosine-protein phosphatase non-receptor type 22
Cysteine 227 of Tyrosine-protein phosphatase non-receptor type 22
2qct B 227 B 238
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 22 between cysteines 227 and 238. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
2qct
Structure name
structure of lyp with inhibitor i-c11
Structure deposition date
2007-06-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
9
% buried
100
Peptide accession
Q9Y2R2
Residue number A
227
Residue number B
238
Peptide name
Tyrosine-protein phosphatase non-receptor type 22
Ligandability
Cysteine 227 of Tyrosine-protein phosphatase non-receptor type 22
Cysteine 238 of Tyrosine-protein phosphatase non-receptor type 22
2qct B 231 B 238
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 22 between cysteines 231 and 238. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
2qct
Structure name
structure of lyp with inhibitor i-c11
Structure deposition date
2007-06-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
100
Peptide accession
Q9Y2R2
Residue number A
231
Residue number B
238
Peptide name
Tyrosine-protein phosphatase non-receptor type 22
Ligandability
Cysteine 231 of Tyrosine-protein phosphatase non-receptor type 22
Cysteine 238 of Tyrosine-protein phosphatase non-receptor type 22
2qct A 224 A 238
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 22 between cysteines 224 and 238. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
20
PDB code
2qct
Structure name
structure of lyp with inhibitor i-c11
Structure deposition date
2007-06-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
97
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Y2R2
Residue number A
224
Residue number B
238
Peptide name
Tyrosine-protein phosphatase non-receptor type 22
Ligandability
Cysteine 224 of Tyrosine-protein phosphatase non-receptor type 22
Cysteine 238 of Tyrosine-protein phosphatase non-receptor type 22
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