a tool for identifying drug-targetable redox-active disulphides

Inner nuclear membrane protein Man1

Intramolecular

Cysteine 684 and cysteine 754

A redox-regulated disulphide may form within Inner nuclear membrane protein Man1 between cysteines 684 and 754 (35 and 105 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

54

PDB code

Structure name

solution structure of the human man1 c-terminal domain (residues 655- 775)

Structure deposition date

2006-03-10

Thiol separation (Å)

8

Half-sphere exposure sum ?

45

Minimum pK_a ?

9

% buried

6

Peptide accession

Residue number A

684

Residue number B

754

Peptide name

Inner nuclear membrane protein Man1

Ligandability

Cysteine 684 of Inner nuclear membrane protein Man1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 754 of Inner nuclear membrane protein Man1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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