ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kelch domain-containing protein 2

Intramolecular
Cysteine 98 and cysteine 325
Cysteine 95 and cysteine 223
A redox-regulated disulphide may form within Kelch domain-containing protein 2 between cysteines 98 and 325. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6do3
Structure name
klhdc2 ubiquitin ligase in complex with selk c-end degron
Structure deposition date
2018-06-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
76
Peptide accession
Q9Y2U9
Residue number A
98
Residue number B
325
Peptide name
Kelch domain-containing protein 2

Ligandability

Cysteine 98 of Kelch domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Kelch domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kelch domain-containing protein 2 between cysteines 95 and 223. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6do4
Structure name
klhdc2 ubiquitin ligase in complex with sels c-end degron
Structure deposition date
2018-06-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y2U9
Residue number A
95
Residue number B
223
Peptide name
Kelch domain-containing protein 2

Ligandability

Cysteine 95 of Kelch domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Kelch domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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