ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calcium-regulated heat-stable protein 1

Intramolecular
Cysteine 67 and cysteine 69
Cysteine 69 and cysteine 71
A redox-regulated disulphide may form within Calcium-regulated heat-stable protein 1 between cysteines 67 and 69. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
3aqq
Structure name
crystal structure of human crhsp-24
Structure deposition date
2010-11-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
34
Peptide accession
Q9Y2V2
Residue number A
67
Residue number B
69
Peptide name
Calcium-regulated heat-stable protein 1

Ligandability

Cysteine 67 of Calcium-regulated heat-stable protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 69 of Calcium-regulated heat-stable protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium-regulated heat-stable protein 1 between cysteines 69 and 71. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3aqq
Structure name
crystal structure of human crhsp-24
Structure deposition date
2010-11-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
2
Peptide accession
Q9Y2V2
Residue number A
69
Residue number B
71
Peptide name
Calcium-regulated heat-stable protein 1

Ligandability

Cysteine 69 of Calcium-regulated heat-stable protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Calcium-regulated heat-stable protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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