Mediator of RNA polymerase II transcription subunit 16
Intramolecular
Cysteine 798 and cysteine 801 L
Cysteine 699 and cysteine 700
Cysteine 801 and cysteine 803 L
Cysteine 801 and cysteine 827 L
Cysteine 798 and cysteine 829
Cysteine 803 and cysteine 827
Cysteine 798 and cysteine 803
Cysteine 717 and cysteine 718
Cysteine 521 and cysteine 532 L
Cysteine 798 and cysteine 827
More...Cysteine 25 and cysteine 74
Cysteine 814 and cysteine 816
Cysteine 468 and cysteine 816
Cysteine 801 and cysteine 829 L
Cysteine 803 and cysteine 829
Cysteine 827 and cysteine 829
7emf P 798 P 801
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 798 and 801.
Details
Redox score ?
67
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9Y2X0
Residue number A
798
Residue number B
801
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 798 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 801 of Mediator of RNA polymerase II transcription subunit 16
7emf P 699 P 700
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 699 and 700.
Details
Redox score ?
65
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
26
Peptide accession
Q9Y2X0
Residue number A
699
Residue number B
700
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 699 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 700 of Mediator of RNA polymerase II transcription subunit 16
7emf P 801 P 803
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 801 and 803.
Details
Redox score ?
61
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
100
Peptide accession
Q9Y2X0
Residue number A
801
Residue number B
803
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 801 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 803 of Mediator of RNA polymerase II transcription subunit 16
7emf P 801 P 827
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 801 and 827.
Details
Redox score ?
61
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
100
Peptide accession
Q9Y2X0
Residue number A
801
Residue number B
827
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 801 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 827 of Mediator of RNA polymerase II transcription subunit 16
7emf P 798 P 829
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 798 and 829.
Details
Redox score ?
61
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
15
% buried
nan
Peptide accession
Q9Y2X0
Residue number A
798
Residue number B
829
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 798 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 829 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 829 in protein B could not be asigned to a Uniprot residue.
7emf P 803 P 827
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 803 and 827. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Y2X0
Residue number A
803
Residue number B
827
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 803 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 827 of Mediator of RNA polymerase II transcription subunit 16
7emf P 798 P 803
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 798 and 803. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
nan
Peptide accession
Q9Y2X0
Residue number A
798
Residue number B
803
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 798 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 803 of Mediator of RNA polymerase II transcription subunit 16
7emf P 717 P 718
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 717 and 718. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
36
Peptide accession
Q9Y2X0
Residue number A
717
Residue number B
718
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 717 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 718 of Mediator of RNA polymerase II transcription subunit 16
6w1s K 521 K 532
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 521 and 532. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
44
Peptide accession
Q6PGF3
Residue number A
521
Residue number B
532
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 521 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 532 of Mediator of RNA polymerase II transcription subunit 16
7emf P 798 P 827
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 798 and 827. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
21
% buried
nan
Peptide accession
Q9Y2X0
Residue number A
798
Residue number B
827
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 798 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 827 of Mediator of RNA polymerase II transcription subunit 16
6w1s K 25 K 74
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 25 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
100
Peptide accession
Q6PGF3
Residue number A
25
Residue number B
74
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 25 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 74 of Mediator of RNA polymerase II transcription subunit 16
6w1s K 814 K 816
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 814 and 816. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
92
Peptide accession
Q6PGF3
Residue number A
814
Residue number B
816
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 814 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 816 of Mediator of RNA polymerase II transcription subunit 16
6w1s K 468 K 816
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 468 and 816. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
96
Peptide accession
Q6PGF3
Residue number A
468
Residue number B
816
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 468 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 816 of Mediator of RNA polymerase II transcription subunit 16
7emf P 801 P 829
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 801 and 829.
Details
Redox score ?
nan
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
100
Peptide accession
Q9Y2X0
Residue number A
801
Residue number B
829
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 801 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 829 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 829 in protein B could not be asigned to a Uniprot residue.
7emf P 803 P 829
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 803 and 829.
Details
Redox score ?
nan
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Y2X0
Residue number A
803
Residue number B
829
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 803 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 829 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 829 in protein B could not be asigned to a Uniprot residue.
7emf P 827 P 829
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 16 between cysteines 827 and 829.
Details
Redox score ?
nan
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
15
% buried
100
Peptide accession
Q9Y2X0
Residue number A
827
Residue number B
829
Peptide name
Mediator of RNA polymerase II transcription subunit 16
Ligandability
Cysteine 827 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 829 of Mediator of RNA polymerase II transcription subunit 16
Cysteine 829 in protein B could not be asigned to a Uniprot residue.
If this tool was useful for finding a disulphide, please cite: