ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ARF GTPase-activating protein GIT1

Intramolecular
Cysteine 725 and cysteine 749
Cysteine 683 and cysteine 725
A redox-regulated disulphide may form within ARF GTPase-activating protein GIT1 between cysteines 725 and 749. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6jmu
Structure name
crystal structure of git1/paxillin complex
Structure deposition date
2019-03-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
75
Peptide accession
Q68FF6
Residue number A
725
Residue number B
749
Peptide name
ARF GTPase-activating protein GIT1

Ligandability

Cysteine 725 of ARF GTPase-activating protein GIT1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 749 of ARF GTPase-activating protein GIT1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ARF GTPase-activating protein GIT1 between cysteines 683 and 725. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6jmu
Structure name
crystal structure of git1/paxillin complex
Structure deposition date
2019-03-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
86
Peptide accession
Q68FF6
Residue number A
683
Residue number B
725
Peptide name
ARF GTPase-activating protein GIT1

Ligandability

Cysteine 683 of ARF GTPase-activating protein GIT1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 725 of ARF GTPase-activating protein GIT1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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