DNA-directed RNA polymerase III subunit RPC10
Intermolecular
Cysteine 70 of DNA-directed RNA polymerase III subunit RPC5 and cysteine 20
Cysteine 25 and cysteine 70 of DNA-directed RNA polymerase III subunit RPC5
Cysteine 1126 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 20
Intramolecular
Cysteine 72 and cysteine 102
Cysteine 69 and cysteine 97
Cysteine 69 and cysteine 72
Cysteine 98 and cysteine 102
Cysteine 25 and cysteine 28
Cysteine 72 and cysteine 97
Cysteine 5 and cysteine 25
More...Cysteine 97 and cysteine 102
Cysteine 8 and cysteine 28
Cysteine 69 and cysteine 102
Cysteine 97 and cysteine 98
Cysteine 5 and cysteine 8
Cysteine 8 and cysteine 25
Cysteine 69 and cysteine 98
Cysteine 72 and cysteine 98
Cysteine 5 and cysteine 28
Cysteine 20 and cysteine 28
7du2 M 70 I 20
A redox-regulated disulphide may form between cysteine 70 of DNA-directed RNA polymerase III subunit RPC5 and cysteine 20 of DNA-directed RNA polymerase III subunit RPC10. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7du2
Structure name
rna polymerase iii ec complex in post-translocation state
Structure deposition date
2021-01-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
24
Peptide A name
DNA-directed RNA polymerase III subunit RPC5
Peptide B name
DNA-directed RNA polymerase III subunit RPC10
Peptide A accession
Q9NVU0
Peptide B accession
Q9Y2Y1
Peptide A residue number
70
Peptide B residue number
20
Ligandability
Cysteine 70 of DNA-directed RNA polymerase III subunit RPC5
Cysteine 20 of DNA-directed RNA polymerase III subunit RPC10
7d58 I 25 M 70
A redox-regulated disulphide may form between cysteine 25 of DNA-directed RNA polymerase III subunit RPC10 and cysteine 70 of DNA-directed RNA polymerase III subunit RPC5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7d58
Structure name
cryo-em structure of human rna polymerase iii in elongating state
Structure deposition date
2020-09-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
nan
Peptide A name
DNA-directed RNA polymerase III subunit RPC10
Peptide B name
DNA-directed RNA polymerase III subunit RPC5
Peptide A accession
Q9Y2Y1
Peptide B accession
Q9NVU0
Peptide A residue number
25
Peptide B residue number
70
Ligandability
Cysteine 25 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 70 of DNA-directed RNA polymerase III subunit RPC5
7d59 A 1126 I 20
A redox-regulated disulphide may form between cysteine 1126 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 20 of DNA-directed RNA polymerase III subunit RPC10. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7d59
Structure name
cryo-em structure of human rna polymerase iii in apo state
Structure deposition date
2020-09-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
30
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerase III subunit RPC10
Peptide A accession
O14802
Peptide B accession
Q9Y2Y1
Peptide A residue number
1126
Peptide B residue number
20
Ligandability
Cysteine 1126 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 20 of DNA-directed RNA polymerase III subunit RPC10
7a6h I 72 I 102
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 72 and 102.
Details
Redox score ?
87
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
8
% buried
0
Peptide accession
Q9Y2Y1
Residue number A
72
Residue number B
102
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 102 of DNA-directed RNA polymerase III subunit RPC10
7fji I 69 I 97
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 69 and 97.
Details
Redox score ?
86
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
27
Peptide accession
Q9Y2Y1
Residue number A
69
Residue number B
97
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 69 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 97 of DNA-directed RNA polymerase III subunit RPC10
7fji I 69 I 72
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 69 and 72.
Details
Redox score ?
84
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
20
Peptide accession
Q9Y2Y1
Residue number A
69
Residue number B
72
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 69 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC10
7d58 I 98 I 102
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 98 and 102.
Details
Redox score ?
82
PDB code
7d58
Structure name
cryo-em structure of human rna polymerase iii in elongating state
Structure deposition date
2020-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
4
Peptide accession
Q9Y2Y1
Residue number A
98
Residue number B
102
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 98 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 102 of DNA-directed RNA polymerase III subunit RPC10
7aea I 25 I 28
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 25 and 28.
Details
Redox score ?
81
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
4
% buried
100
Peptide accession
Q9Y2Y1
Residue number A
25
Residue number B
28
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 25 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 28 of DNA-directed RNA polymerase III subunit RPC10
7ae1 I 72 I 97
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 72 and 97.
Details
Redox score ?
78
PDB code
7ae1
Structure name
cryo-em structure of human rna polymerase iii elongation complex 1
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
0
Peptide accession
Q9Y2Y1
Residue number A
72
Residue number B
97
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 97 of DNA-directed RNA polymerase III subunit RPC10
7dn3 I 5 I 25
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 5 and 25.
Details
Redox score ?
74
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
5
% buried
nan
Peptide accession
Q9Y2Y1
Residue number A
5
Residue number B
25
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 5 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 25 of DNA-directed RNA polymerase III subunit RPC10
7ae3 I 97 I 102
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 97 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7ae3
Structure name
cryo-em structure of human rna polymerase iii elongation complex 3
Structure deposition date
2020-09-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
11
Peptide accession
Q9Y2Y1
Residue number A
97
Residue number B
102
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 97 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 102 of DNA-directed RNA polymerase III subunit RPC10
7fjj I 8 I 28
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 8 and 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7fjj
Structure name
human pol iii pre-termination complex
Structure deposition date
2021-08-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
14
% buried
100
Peptide accession
Q9Y2Y1
Residue number A
8
Residue number B
28
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 8 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 28 of DNA-directed RNA polymerase III subunit RPC10
7d59 I 69 I 102
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 69 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7d59
Structure name
cryo-em structure of human rna polymerase iii in apo state
Structure deposition date
2020-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
3
Peptide accession
Q9Y2Y1
Residue number A
69
Residue number B
102
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 69 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 102 of DNA-directed RNA polymerase III subunit RPC10
7d58 I 97 I 98
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 97 and 98. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7d58
Structure name
cryo-em structure of human rna polymerase iii in elongating state
Structure deposition date
2020-09-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
34
Peptide accession
Q9Y2Y1
Residue number A
97
Residue number B
98
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 97 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 98 of DNA-directed RNA polymerase III subunit RPC10
7dn3 I 5 I 8
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 5 and 8. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
20
% buried
nan
Peptide accession
Q9Y2Y1
Residue number A
5
Residue number B
8
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 5 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 8 of DNA-directed RNA polymerase III subunit RPC10
7ast A 8 A 25
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 8 and 25. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9Y2Y1
Residue number A
8
Residue number B
25
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 8 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 25 of DNA-directed RNA polymerase III subunit RPC10
7ae3 I 69 I 98
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 69 and 98. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7ae3
Structure name
cryo-em structure of human rna polymerase iii elongation complex 3
Structure deposition date
2020-09-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
6
% buried
30
Peptide accession
Q9Y2Y1
Residue number A
69
Residue number B
98
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 69 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 98 of DNA-directed RNA polymerase III subunit RPC10
7a6h I 72 I 98
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 72 and 98. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
0
Peptide accession
Q9Y2Y1
Residue number A
72
Residue number B
98
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 98 of DNA-directed RNA polymerase III subunit RPC10
7aea I 5 I 28
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 5 and 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
24
% buried
nan
Peptide accession
Q9Y2Y1
Residue number A
5
Residue number B
28
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 5 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 28 of DNA-directed RNA polymerase III subunit RPC10
7du2 I 20 I 28
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC10 between cysteines 20 and 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7du2
Structure name
rna polymerase iii ec complex in post-translocation state
Structure deposition date
2021-01-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
56
Peptide accession
Q9Y2Y1
Residue number A
20
Residue number B
28
Peptide name
DNA-directed RNA polymerase III subunit RPC10
Ligandability
Cysteine 20 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 28 of DNA-directed RNA polymerase III subunit RPC10
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