ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribosome maturation protein SBDS

Intermolecular
Cysteine 210 and cysteine 934 of Elongation factor-like GTPase 1
Intramolecular
Cysteine 31 and cysteine 84
Cysteine 119 and cysteine 216
Cysteine 210 and cysteine 216
A redox-regulated disulphide may form between cysteine 210 of Ribosome maturation protein SBDS and cysteine 934 of Elongation factor-like GTPase 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5anb
Structure name
mechanism of eif6 release from the nascent 60s ribosomal subunit
Structure deposition date
2015-09-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
90
Peptide A name
Ribosome maturation protein SBDS
Peptide B name
Elongation factor-like GTPase 1
Peptide A accession
Q9Y3A5
Peptide B accession
Q7Z2Z2
Peptide A residue number
210
Peptide B residue number
934

Ligandability

Cysteine 210 of Ribosome maturation protein SBDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 934 of Elongation factor-like GTPase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribosome maturation protein SBDS between cysteines 31 and 84 (33 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
2kdo
Structure name
structure of the human shwachman-bodian-diamond syndrome protein, sbds
Structure deposition date
2009-01-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
74
Peptide accession
Q9Y3A5
Residue number A
31
Residue number B
84
Peptide name
Ribosome maturation protein SBDS

Ligandability

Cysteine 31 of Ribosome maturation protein SBDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Ribosome maturation protein SBDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribosome maturation protein SBDS between cysteines 119 and 216. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2l9n
Structure name
structure of the human shwachman-bodian-diamond syndrome (sbds) protein
Structure deposition date
2011-02-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
48
Peptide accession
Q9Y3A5
Residue number A
119
Residue number B
216
Peptide name
Ribosome maturation protein SBDS

Ligandability

Cysteine 119 of Ribosome maturation protein SBDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Ribosome maturation protein SBDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribosome maturation protein SBDS between cysteines 210 and 216 (212 and 218 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2kdo
Structure name
structure of the human shwachman-bodian-diamond syndrome protein, sbds
Structure deposition date
2009-01-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
50
Peptide accession
Q9Y3A5
Residue number A
210
Residue number B
216
Peptide name
Ribosome maturation protein SBDS

Ligandability

Cysteine 210 of Ribosome maturation protein SBDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Ribosome maturation protein SBDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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