ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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28S ribosomal protein S16, mitochondrial

Intermolecular
Cysteine 26 and cysteine 149 of 28S ribosomal protein S25, mitochondrial L
Cysteine 26 and cysteine 141 of 28S ribosomal protein S25, mitochondrial L
Cysteine 26 and cysteine 139 of 28S ribosomal protein S25, mitochondrial L
A redox-regulated disulphide may form between cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 149 of 28S ribosomal protein S25, mitochondrial.

Details

Redox score ?
90
PDB code
8csp
Structure name
human mitochondrial small subunit assembly intermediate (state a)
Structure deposition date
2022-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
3
% buried
64
Peptide A name
28S ribosomal protein S16, mitochondrial
Peptide B name
28S ribosomal protein S25, mitochondrial
Peptide A accession
Q9Y3D3
Peptide B accession
P82663
Peptide A residue number
26
Peptide B residue number
149

Ligandability

Cysteine 26 of 28S ribosomal protein S16, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of 28S ribosomal protein S25, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 141 of 28S ribosomal protein S25, mitochondrial.

Details

Redox score ?
73
PDB code
3jd5
Structure name
cryo-em structure of the small subunit of the mammalian mitochondrial ribosome
Structure deposition date
2016-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
36
Peptide A name
28S ribosomal protein S16, mitochondrial
Peptide B name
28S ribosomal protein S25, mitochondrial
Peptide A accession
P82915
Peptide B accession
P82669
Peptide A residue number
26
Peptide B residue number
141

Ligandability

Cysteine 26 of 28S ribosomal protein S16, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of 28S ribosomal protein S25, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 26 of 28S ribosomal protein S16, mitochondrial and cysteine 139 of 28S ribosomal protein S25, mitochondrial.

Details

Redox score ?
62
PDB code
8cst
Structure name
human mitochondrial small subunit assembly intermediate (state e)
Structure deposition date
2022-05-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
74
Peptide A name
28S ribosomal protein S16, mitochondrial
Peptide B name
28S ribosomal protein S25, mitochondrial
Peptide A accession
Q9Y3D3
Peptide B accession
P82663
Peptide A residue number
26
Peptide B residue number
139

Ligandability

Cysteine 26 of 28S ribosomal protein S16, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of 28S ribosomal protein S25, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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