a tool for identifying drug-targetable redox-active disulphides

RNA-splicing ligase RtcB homolog

Intramolecular

Cysteine 427 and cysteine 485

A redox-regulated disulphide may form within RNA-splicing ligase RtcB homolog between cysteines 427 and 485.

Details

Redox score ?

65

PDB code

Structure name

human rna ligase rtcb in complex with gmp and co(ii)

Structure deposition date

2021-07-07

Thiol separation (Å)

4

Half-sphere exposure sum ?

105

Minimum pK_a ?

9

% buried

100

Peptide accession

Residue number A

427

Residue number B

485

Peptide name

RNA-splicing ligase RtcB homolog

Ligandability

Cysteine 427 of RNA-splicing ligase RtcB homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 485 of RNA-splicing ligase RtcB homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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