ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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StAR-related lipid transfer protein 13

Intramolecular
Cysteine 1070 and cysteine 1090
Cysteine 64 and cysteine 116
A redox-regulated disulphide may form within StAR-related lipid transfer protein 13 between cysteines 1070 and 1090.

Details

Redox score ?
67
PDB code
2pso
Structure name
human stard13 (dlc2) lipid transfer and protein localization domain
Structure deposition date
2007-05-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
100
Peptide accession
Q9Y3M8
Residue number A
1070
Residue number B
1090
Peptide name
StAR-related lipid transfer protein 13

Ligandability

Cysteine 1070 of StAR-related lipid transfer protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1090 of StAR-related lipid transfer protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within StAR-related lipid transfer protein 13 between cysteines 64 and 116 (25 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2jw2
Structure name
validation of inter-helical orientation of the steril-alpha-motif of human deleted in liver cancer 2 by residual dipolar couplings
Structure deposition date
2007-10-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
16
Peptide accession
Q9Y3M8
Residue number A
64
Residue number B
116
Peptide name
StAR-related lipid transfer protein 13

Ligandability

Cysteine 64 of StAR-related lipid transfer protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of StAR-related lipid transfer protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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