Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 at cysteines 479 and 479. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7np4

Structure name

camp-bound rabbit hcn4 stabilized in lmng-chs detergent mixture

Structure deposition date

2021-02-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide A name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Peptide B name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Peptide A accession

Q9TV66

Peptide B accession

Q9TV66

Peptide A residue number

479

Peptide B residue number

479

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 between cysteines 429 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6gyo

Structure name

structure of human hcn4 hyperpolarization-activated cyclic nucleotide- gated ion channel in complex with camp

Structure deposition date

2018-06-30

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Q9Y3Q4

Residue number A

429

Residue number B

434

Peptide name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Ligandability

Cysteine 429 of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 434 of Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 between cysteines 429 and 505. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?