ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sialidase-2

Intramolecular
Cysteine 196 and cysteine 219
Cysteine 88 and cysteine 164
Cysteine 164 and cysteine 196
Cysteine 272 and cysteine 332
Cysteine 332 and cysteine 352
Cysteine 164 and cysteine 219
Cysteine 88 and cysteine 219
A redox-regulated disulphide may form within Sialidase-2 between cysteines 196 and 219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2f25
Structure name
crystal structure of the human sialidase neu2 e111q mutant in complex with dana inhibitor
Structure deposition date
2005-11-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
97
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y3R4
Residue number A
196
Residue number B
219
Peptide name
Sialidase-2

Ligandability

Cysteine 196 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sialidase-2 between cysteines 88 and 164. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1snt
Structure name
structure of the human cytosolic sialidase neu2
Structure deposition date
2004-03-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
94
Minimum pKa ?
11
% buried
100
Peptide accession
Q9Y3R4
Residue number A
88
Residue number B
164
Peptide name
Sialidase-2

Ligandability

Cysteine 88 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sialidase-2 between cysteines 164 and 196. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2f0z
Structure name
crystal structure of the human sialidase neu2 in complex with zanamivir inhibitor
Structure deposition date
2005-11-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y3R4
Residue number A
164
Residue number B
196
Peptide name
Sialidase-2

Ligandability

Cysteine 164 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sialidase-2 between cysteines 272 and 332. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2f11
Structure name
crystal structure of the human sialidase neu2 in complex with isobutyl ether mimetic inhibitor
Structure deposition date
2005-11-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
88
Peptide accession
Q9Y3R4
Residue number A
272
Residue number B
332
Peptide name
Sialidase-2

Ligandability

Cysteine 272 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 332 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sialidase-2 between cysteines 332 and 352. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
1vcu
Structure name
structure of the human cytosolic sialidase neu2 in complex with the inhibitor dana
Structure deposition date
2004-03-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
92
Peptide accession
Q9Y3R4
Residue number A
332
Residue number B
352
Peptide name
Sialidase-2

Ligandability

Cysteine 332 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 352 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sialidase-2 between cysteines 164 and 219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
2f25
Structure name
crystal structure of the human sialidase neu2 e111q mutant in complex with dana inhibitor
Structure deposition date
2005-11-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y3R4
Residue number A
164
Residue number B
219
Peptide name
Sialidase-2

Ligandability

Cysteine 164 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sialidase-2 between cysteines 88 and 219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
22
PDB code
2f11
Structure name
crystal structure of the human sialidase neu2 in complex with isobutyl ether mimetic inhibitor
Structure deposition date
2005-11-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
99
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y3R4
Residue number A
88
Residue number B
219
Peptide name
Sialidase-2

Ligandability

Cysteine 88 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Sialidase-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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