a tool for identifying drug-targetable redox-active disulphides

Nuclear receptor subfamily 2 group E member 1

Intramolecular

Cysteine 287 and cysteine 290

A redox-regulated disulphide may form within Nuclear receptor subfamily 2 group E member 1 between cysteines 287 and 290 (1287 and 1290 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

crystal structure of human nr2e1/tlx

Structure deposition date

2014-12-14

Thiol separation (Å)

7

Half-sphere exposure sum ?

78

Minimum pK_a ?

11

% buried

67

Peptide accession

Residue number A

287

Residue number B

290

Peptide name

Nuclear receptor subfamily 2 group E member 1

Ligandability

Cysteine 287 of Nuclear receptor subfamily 2 group E member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 290 of Nuclear receptor subfamily 2 group E member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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