ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lethal(3)malignant brain tumor-like protein 1

Intramolecular
Cysteine 332 and cysteine 575
Cysteine 431 and cysteine 471
A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 1 between cysteines 332 and 575 (264 and 507 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3p8h
Structure name
crystal structure of l3mbtl1 (mbt repeat) in complex with a nicotinamide antagonist
Structure deposition date
2010-10-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
56
Peptide accession
Q9Y468
Residue number A
332
Residue number B
575
Peptide name
Lethal(3)malignant brain tumor-like protein 1

Ligandability

Cysteine 332 of Lethal(3)malignant brain tumor-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 575 of Lethal(3)malignant brain tumor-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 1 between cysteines 431 and 471 (363 and 403 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2ri2
Structure name
crystal structure of the 3-mbt repeats from human l3mbtl1 with d355a point mutation
Structure deposition date
2007-10-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
48
Peptide accession
Q9Y468
Residue number A
431
Residue number B
471
Peptide name
Lethal(3)malignant brain tumor-like protein 1

Ligandability

Cysteine 431 of Lethal(3)malignant brain tumor-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of Lethal(3)malignant brain tumor-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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