5'-AMP-activated protein kinase subunit beta-1
Intermolecular
Cysteine 425 of 5'-AMP-activated protein kinase catalytic subunit alpha-1 and cysteine 194
6c9f A 416 B 194
A redox-regulated disulphide may form between cysteine 425 of 5'-AMP-activated protein kinase catalytic subunit alpha-1 and cysteine 194 of 5'-AMP-activated protein kinase subunit beta-1 (416 and 194 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6c9f
Structure name
amp-activated protein kinase bound to pharmacological activator r734
Structure deposition date
2018-01-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
28
Peptide A name
5'-AMP-activated protein kinase catalytic subunit alpha-1
Peptide B name
5'-AMP-activated protein kinase subunit beta-1
Peptide A accession
Q13131
Peptide B accession
Q9Y478
Peptide A residue number
425
Peptide B residue number
194
Ligandability
Cysteine 425 of 5'-AMP-activated protein kinase catalytic subunit alpha-1
Cysteine 194 of 5'-AMP-activated protein kinase subunit beta-1
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