Talin-1
Intermolecular
Cysteine 575 and cysteine 575
Intramolecular
Cysteine 709 and cysteine 750
Cysteine 1199 and cysteine 1202 L
Cysteine 1506 and cysteine 1509
Cysteine 1486 and cysteine 1558 L
Cysteine 243 and cysteine 286 L
Cysteine 1927 and cysteine 1953
Cysteine 956 and cysteine 1023
Cysteine 1478 and cysteine 1558 L
Cysteine 719 and cysteine 732 L
More...Cysteine 2219 and cysteine 2243
Cysteine 236 and cysteine 243 L
Cysteine 2161 and cysteine 2219
Cysteine 575 and cysteine 1023
5nl1 A 575 B 575
A redox-regulated disulphide may form between two units of Talin-1 at cysteines 575 and 575.
Details
Redox score ?
75
PDB code
5nl1
Structure name
shigella ipaa-vbs3/tbs in complex with the talin vbs1 domain 488-512
Structure deposition date
2017-04-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
6
% buried
95
Peptide A name
Talin-1
Peptide B name
Talin-1
Peptide A accession
P26039
Peptide B accession
P26039
Peptide A residue number
575
Peptide B residue number
575
Ligandability
6r9t A 709 A 750
A redox-regulated disulphide may form within Talin-1 between cysteines 709 and 750.
Details
Redox score ?
70
PDB code
6r9t
Structure name
cryo-em structure of autoinhibited human talin-1
Structure deposition date
2019-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
7
% buried
60
Peptide accession
Q9Y490
Residue number A
709
Residue number B
750
Peptide name
Talin-1
Ligandability
Cysteine 709 of Talin-1
Cysteine 750 of Talin-1
2l7n A 1199 A 1202
A redox-regulated disulphide may form within Talin-1 between cysteines 1199 and 1202.
Details
Redox score ?
69
PDB code
2l7n
Structure name
solution structure of the r5 domain of talin
Structure deposition date
2010-12-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
54
Peptide accession
P26039
Residue number A
1199
Residue number B
1202
Peptide name
Talin-1
Ligandability
Cysteine 1199 of Talin-1
Cysteine 1202 of Talin-1
5ic1 A 1506 A 1509
A redox-regulated disulphide may form within Talin-1 between cysteines 1506 and 1509. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5ic1
Structure name
structural analysis of a talin triple domain module, e1794y, e1797y, q1801y mutant
Structure deposition date
2016-02-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
57
Peptide accession
P26039
Residue number A
1506
Residue number B
1509
Peptide name
Talin-1
Ligandability
Cysteine 1506 of Talin-1
Cysteine 1509 of Talin-1
4w8p A 1486 A 1558
A redox-regulated disulphide may form within Talin-1 between cysteines 1486 and 1558. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
4w8p
Structure name
crystal structure of riam tbs1 in complex with talin r7r8 domains
Structure deposition date
2014-08-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
41
Peptide accession
P26039
Residue number A
1486
Residue number B
1558
Peptide name
Talin-1
Ligandability
Cysteine 1486 of Talin-1
Cysteine 1558 of Talin-1
6r9t A 243 A 286
A redox-regulated disulphide may form within Talin-1 between cysteines 243 and 286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6r9t
Structure name
cryo-em structure of autoinhibited human talin-1
Structure deposition date
2019-04-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
55
Peptide accession
Q9Y490
Residue number A
243
Residue number B
286
Peptide name
Talin-1
Ligandability
Cysteine 243 of Talin-1
Cysteine 286 of Talin-1
2kvp A 1927 A 1953
A redox-regulated disulphide may form within Talin-1 between cysteines 1927 and 1953. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
2kvp
Structure name
solution structure of the r10 domain of talin
Structure deposition date
2010-03-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
10
% buried
75
Peptide accession
P26039
Residue number A
1927
Residue number B
1953
Peptide name
Talin-1
Ligandability
Cysteine 1927 of Talin-1
Cysteine 1953 of Talin-1
2lqg A 956 A 1023
A redox-regulated disulphide may form within Talin-1 between cysteines 956 and 1023. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
2lqg
Structure name
solution structure of the r4 domain of talin
Structure deposition date
2012-03-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
36
Peptide accession
P26039
Residue number A
956
Residue number B
1023
Peptide name
Talin-1
Ligandability
Cysteine 956 of Talin-1
Cysteine 1023 of Talin-1
6twn A 1478 A 1558
A redox-regulated disulphide may form within Talin-1 between cysteines 1478 and 1558. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6twn
Structure name
crystal structure of talin1 r7r8 in complex with cdk1 (206-223)
Structure deposition date
2020-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
75
Peptide accession
P26039
Residue number A
1478
Residue number B
1558
Peptide name
Talin-1
Ligandability
Cysteine 1478 of Talin-1
Cysteine 1558 of Talin-1
1sj8 A 719 A 732
A redox-regulated disulphide may form within Talin-1 between cysteines 719 and 732. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
1sj8
Structure name
solution structure of the r1r2 domains of talin
Structure deposition date
2004-03-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
88
Peptide accession
P26039
Residue number A
719
Residue number B
732
Peptide name
Talin-1
Ligandability
Cysteine 719 of Talin-1
Cysteine 732 of Talin-1
6r9t A 2219 A 2243
A redox-regulated disulphide may form within Talin-1 between cysteines 2219 and 2243. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6r9t
Structure name
cryo-em structure of autoinhibited human talin-1
Structure deposition date
2019-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
92
Peptide accession
Q9Y490
Residue number A
2219
Residue number B
2243
Peptide name
Talin-1
Ligandability
Cysteine 2219 of Talin-1
Cysteine 2243 of Talin-1
6vgu A 236 A 243
A redox-regulated disulphide may form within Talin-1 between cysteines 236 and 243. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6vgu
Structure name
crystal structure of ferm-folded talin head domain bound to the nply motif of beta3-integrin
Structure deposition date
2020-01-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
62
Peptide accession
P26039
Residue number A
236
Residue number B
243
Peptide name
Talin-1
Ligandability
Cysteine 236 of Talin-1
Cysteine 243 of Talin-1
3dyj A 2161 A 2219
A redox-regulated disulphide may form within Talin-1 between cysteines 2161 and 2219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
3dyj
Structure name
crystal structure of the r11r12 domains of talin
Structure deposition date
2008-07-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
P26039
Residue number A
2161
Residue number B
2219
Peptide name
Talin-1
Ligandability
Cysteine 2161 of Talin-1
Cysteine 2219 of Talin-1
6r9t A 575 A 1023
A redox-regulated disulphide may form within Talin-1 between cysteines 575 and 1023. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
6r9t
Structure name
cryo-em structure of autoinhibited human talin-1
Structure deposition date
2019-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
94
Peptide accession
Q9Y490
Residue number A
575
Residue number B
1023
Peptide name
Talin-1
Ligandability
Cysteine 575 of Talin-1
Cysteine 1023 of Talin-1
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