DDB1- and CUL4-associated factor 1
Intermolecular
Cysteine 1113 and cysteine 73 of Protein Vpx
Cysteine 784 and cysteine 784
Intramolecular
Cysteine 1019 and cysteine 1037
Cysteine 1099 and cysteine 1358
Cysteine 1099 and cysteine 1384
Cysteine 712 and cysteine 521
Cysteine 451 and cysteine 457
Cysteine 1358 and cysteine 1384
Cysteine 1026 and cysteine 1037
Cysteine 1019 and cysteine 1026
More...Cysteine 1098 and cysteine 1099
Cysteine 457 and cysteine 458
Cysteine 431 and cysteine 467
Cysteine 1098 and cysteine 1133
Cysteine 759 and cysteine 806
Cysteine 690 and cysteine 759
Cysteine 1098 and cysteine 1358
Cysteine 1098 and cysteine 1384
4cc9 A 1113 B 73
A redox-regulated disulphide may form between cysteine 1113 of DDB1- and CUL4-associated factor 1 and cysteine 73 of Protein Vpx.
Details
Redox score ?
64
PDB code
4cc9
Structure name
crystal structure of human samhd1 (amino acid residues 582-626) bound to vpx isolated from sooty mangabey and human dcaf1 (amino acid residues 1058-1396)
Structure deposition date
2013-10-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide A name
DDB1- and CUL4-associated factor 1
Peptide B name
Protein Vpx
Peptide A accession
Q9Y4B6
Peptide B accession
P19508
Peptide A residue number
1113
Peptide B residue number
73
Ligandability
Cysteine 1113 of DDB1- and CUL4-associated factor 1
Cysteine 73 of Protein Vpx
7v7c A 784 E 784
A redox-regulated disulphide may form between two units of DDB1- and CUL4-associated factor 1 at cysteines 784 and 784. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7v7c
Structure name
cryoem structure of ddb1-vprbp-vpr-ung2(94-313) complex
Structure deposition date
2021-08-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
42
Minimum pKa ?
8
% buried
23
Peptide A name
DDB1- and CUL4-associated factor 1
Peptide B name
DDB1- and CUL4-associated factor 1
Peptide A accession
Q9Y4B6
Peptide B accession
Q9Y4B6
Peptide A residue number
784
Peptide B residue number
784
Ligandability
7v7b A 1019 A 1037
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1019 and 1037.
Details
Redox score ?
88
PDB code
7v7b
Structure name
cryoem structure of ddb1-vprbp complex in arm-up conformation
Structure deposition date
2021-08-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y4B6
Residue number A
1019
Residue number B
1037
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1019 of DDB1- and CUL4-associated factor 1
Cysteine 1037 of DDB1- and CUL4-associated factor 1
4cc9 A 1099 A 1358
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1099 and 1358.
Details
Redox score ?
69
PDB code
4cc9
Structure name
crystal structure of human samhd1 (amino acid residues 582-626) bound to vpx isolated from sooty mangabey and human dcaf1 (amino acid residues 1058-1396)
Structure deposition date
2013-10-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
100
Peptide accession
Q9Y4B6
Residue number A
1099
Residue number B
1358
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1099 of DDB1- and CUL4-associated factor 1
Cysteine 1358 of DDB1- and CUL4-associated factor 1
4pxw A 1099 A 1384
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1099 and 1384.
Details
Redox score ?
62
PDB code
4pxw
Structure name
crystal structure of human dcaf1 wd40 repeats (q1250l)
Structure deposition date
2014-03-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y4B6
Residue number A
1099
Residue number B
1384
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1099 of DDB1- and CUL4-associated factor 1
Cysteine 1384 of DDB1- and CUL4-associated factor 1
6n45 B 712 B 779
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 712 and 521 (712 and 779 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6n45
Structure name
crystal structure of the cryptic polo box domain of human activated plk4 variant 1
Structure deposition date
2018-11-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
84
Peptide accession
Q9Y4B6
Residue number A
712
Residue number B
521
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 712 of DDB1- and CUL4-associated factor 1
Cysteine 521 of DDB1- and CUL4-associated factor 1
Cysteine 712 in protein A could not be asigned to a Uniprot residue.
7v7b A 451 A 457
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 451 and 457. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7v7b
Structure name
cryoem structure of ddb1-vprbp complex in arm-up conformation
Structure deposition date
2021-08-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
45
Peptide accession
Q9Y4B6
Residue number A
451
Residue number B
457
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 451 of DDB1- and CUL4-associated factor 1
Cysteine 457 of DDB1- and CUL4-associated factor 1
4pxw A 1358 A 1384
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1358 and 1384. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
4pxw
Structure name
crystal structure of human dcaf1 wd40 repeats (q1250l)
Structure deposition date
2014-03-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y4B6
Residue number A
1358
Residue number B
1384
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1358 of DDB1- and CUL4-associated factor 1
Cysteine 1384 of DDB1- and CUL4-associated factor 1
7v7c E 1026 E 1037
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1026 and 1037. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7v7c
Structure name
cryoem structure of ddb1-vprbp-vpr-ung2(94-313) complex
Structure deposition date
2021-08-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9Y4B6
Residue number A
1026
Residue number B
1037
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1026 of DDB1- and CUL4-associated factor 1
Cysteine 1037 of DDB1- and CUL4-associated factor 1
7v7c E 1019 E 1026
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1019 and 1026. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7v7c
Structure name
cryoem structure of ddb1-vprbp-vpr-ung2(94-313) complex
Structure deposition date
2021-08-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9Y4B6
Residue number A
1019
Residue number B
1026
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1019 of DDB1- and CUL4-associated factor 1
Cysteine 1026 of DDB1- and CUL4-associated factor 1
5aja A 1098 A 1099
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1098 and 1099. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5aja
Structure name
crystal structure of mandrill samhd1 (amino acid residues 1-114) bound to vpx isolated from mandrill and human dcaf1 (amino acid residues 1058-1396)
Structure deposition date
2015-02-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
91
Minimum pKa ?
14
% buried
100
Peptide accession
Q9Y4B6
Residue number A
1098
Residue number B
1099
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1098 of DDB1- and CUL4-associated factor 1
Cysteine 1099 of DDB1- and CUL4-associated factor 1
7v7c A 457 A 458
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 457 and 458. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7v7c
Structure name
cryoem structure of ddb1-vprbp-vpr-ung2(94-313) complex
Structure deposition date
2021-08-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
64
Peptide accession
Q9Y4B6
Residue number A
457
Residue number B
458
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 457 of DDB1- and CUL4-associated factor 1
Cysteine 458 of DDB1- and CUL4-associated factor 1
7v7c A 431 A 467
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 431 and 467. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7v7c
Structure name
cryoem structure of ddb1-vprbp-vpr-ung2(94-313) complex
Structure deposition date
2021-08-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
78
Peptide accession
Q9Y4B6
Residue number A
431
Residue number B
467
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 431 of DDB1- and CUL4-associated factor 1
Cysteine 467 of DDB1- and CUL4-associated factor 1
7ufv B 1098 B 1133
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1098 and 1133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7ufv
Structure name
crystal structure of the wdr domain of human dcaf1 in complex with oicr-6766
Structure deposition date
2022-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y4B6
Residue number A
1098
Residue number B
1133
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1098 of DDB1- and CUL4-associated factor 1
Cysteine 1133 of DDB1- and CUL4-associated factor 1
7v7c E 759 E 806
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 759 and 806. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7v7c
Structure name
cryoem structure of ddb1-vprbp-vpr-ung2(94-313) complex
Structure deposition date
2021-08-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
62
Peptide accession
Q9Y4B6
Residue number A
759
Residue number B
806
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 759 of DDB1- and CUL4-associated factor 1
Cysteine 806 of DDB1- and CUL4-associated factor 1
7v7b C 690 C 759
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 690 and 759. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7v7b
Structure name
cryoem structure of ddb1-vprbp complex in arm-up conformation
Structure deposition date
2021-08-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
74
Peptide accession
Q9Y4B6
Residue number A
690
Residue number B
759
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 690 of DDB1- and CUL4-associated factor 1
Cysteine 759 of DDB1- and CUL4-associated factor 1
7sse B 1098 B 1358
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1098 and 1358. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7sse
Structure name
crystal structure of the wdr domain of human dcaf1 in complex with cyca-117-70
Structure deposition date
2021-11-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
100
Peptide accession
Q9Y4B6
Residue number A
1098
Residue number B
1358
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1098 of DDB1- and CUL4-associated factor 1
Cysteine 1358 of DDB1- and CUL4-associated factor 1
5jk7 C 1098 C 1384
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 1 between cysteines 1098 and 1384. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
21
PDB code
5jk7
Structure name
the x-ray structure of the ddb1-dcaf1-vpr-ung2 complex
Structure deposition date
2016-04-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Y4B6
Residue number A
1098
Residue number B
1384
Peptide name
DDB1- and CUL4-associated factor 1
Ligandability
Cysteine 1098 of DDB1- and CUL4-associated factor 1
Cysteine 1384 of DDB1- and CUL4-associated factor 1
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