Ubiquitin carboxyl-terminal hydrolase 15
Intramolecular
Cysteine 448 and cysteine 451
Cysteine 451 and cysteine 812
Cysteine 809 and cysteine 812
Cysteine 448 and cysteine 809
Cysteine 451 and cysteine 809
Cysteine 448 and cysteine 812
Cysteine 306 and cysteine 381
Cysteine 298 and cysteine 381
6crn D 448 D 451
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 15 between cysteines 448 and 451.
Details
Redox score ?
90
PDB code
6crn
Structure name
structure of the usp15 deubiquitinase domain in complex with a high- affinity first-generation ubv
Structure deposition date
2018-03-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
0
Peptide accession
Q9Y4E8
Residue number A
448
Residue number B
451
Peptide name
Ubiquitin carboxyl-terminal hydrolase 15
Ligandability
Cysteine 448 of Ubiquitin carboxyl-terminal hydrolase 15
Cysteine 451 of Ubiquitin carboxyl-terminal hydrolase 15
6gh9 A 422 A 783
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 15 between cysteines 451 and 812 (422 and 783 respectively in this structure).
Details
Redox score ?
89
PDB code
6gh9
Structure name
usp15 catalytic domain in complex with small molecule
Structure deposition date
2018-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
6
% buried
0
Peptide accession
Q9Y4E8
Residue number A
451
Residue number B
812
Peptide name
Ubiquitin carboxyl-terminal hydrolase 15
Ligandability
Cysteine 451 of Ubiquitin carboxyl-terminal hydrolase 15
Cysteine 812 of Ubiquitin carboxyl-terminal hydrolase 15
6gh9 A 780 A 783
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 15 between cysteines 809 and 812 (780 and 783 respectively in this structure).
Details
Redox score ?
88
PDB code
6gh9
Structure name
usp15 catalytic domain in complex with small molecule
Structure deposition date
2018-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
8
% buried
0
Peptide accession
Q9Y4E8
Residue number A
809
Residue number B
812
Peptide name
Ubiquitin carboxyl-terminal hydrolase 15
Ligandability
Cysteine 809 of Ubiquitin carboxyl-terminal hydrolase 15
Cysteine 812 of Ubiquitin carboxyl-terminal hydrolase 15
6cpm C 448 C 499
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 15 between cysteines 448 and 809 (448 and 499 respectively in this structure).
Details
Redox score ?
87
PDB code
6cpm
Structure name
structure of the usp15 deubiquitinase domain in complex with a third- generation inhibitory ubv
Structure deposition date
2018-03-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
2
Peptide accession
Q9Y4E8
Residue number A
448
Residue number B
809
Peptide name
Ubiquitin carboxyl-terminal hydrolase 15
Ligandability
Cysteine 448 of Ubiquitin carboxyl-terminal hydrolase 15
Cysteine 809 of Ubiquitin carboxyl-terminal hydrolase 15
6cpm C 451 C 499
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 15 between cysteines 451 and 809 (451 and 499 respectively in this structure).
Details
Redox score ?
85
PDB code
6cpm
Structure name
structure of the usp15 deubiquitinase domain in complex with a third- generation inhibitory ubv
Structure deposition date
2018-03-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
2
Peptide accession
Q9Y4E8
Residue number A
451
Residue number B
809
Peptide name
Ubiquitin carboxyl-terminal hydrolase 15
Ligandability
Cysteine 451 of Ubiquitin carboxyl-terminal hydrolase 15
Cysteine 809 of Ubiquitin carboxyl-terminal hydrolase 15
6crn A 448 A 502
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 15 between cysteines 448 and 812 (448 and 502 respectively in this structure).
Details
Redox score ?
79
PDB code
6crn
Structure name
structure of the usp15 deubiquitinase domain in complex with a high- affinity first-generation ubv
Structure deposition date
2018-03-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9Y4E8
Residue number A
448
Residue number B
812
Peptide name
Ubiquitin carboxyl-terminal hydrolase 15
Ligandability
Cysteine 448 of Ubiquitin carboxyl-terminal hydrolase 15
Cysteine 812 of Ubiquitin carboxyl-terminal hydrolase 15
6cpm C 306 C 381
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 15 between cysteines 306 and 381. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6cpm
Structure name
structure of the usp15 deubiquitinase domain in complex with a third- generation inhibitory ubv
Structure deposition date
2018-03-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y4E8
Residue number A
306
Residue number B
381
Peptide name
Ubiquitin carboxyl-terminal hydrolase 15
Ligandability
Cysteine 306 of Ubiquitin carboxyl-terminal hydrolase 15
Cysteine 381 of Ubiquitin carboxyl-terminal hydrolase 15
6cpm C 298 C 381
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 15 between cysteines 298 and 381. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6cpm
Structure name
structure of the usp15 deubiquitinase domain in complex with a third- generation inhibitory ubv
Structure deposition date
2018-03-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
76
Peptide accession
Q9Y4E8
Residue number A
298
Residue number B
381
Peptide name
Ubiquitin carboxyl-terminal hydrolase 15
Ligandability
Cysteine 298 of Ubiquitin carboxyl-terminal hydrolase 15
Cysteine 381 of Ubiquitin carboxyl-terminal hydrolase 15
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