ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Unconventional myosin-Va

Intramolecular
Cysteine 788 and cysteine 1259
Cysteine 1768 and cysteine 1771
A redox-regulated disulphide may form within Unconventional myosin-Va between cysteines 788 and 1259.

Details

Redox score ?
88
PDB code
2ix7
Structure name
structure of apo-calmodulin bound to unconventional myosin v
Structure deposition date
2006-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99104
Residue number A
788
Residue number B
1259
Peptide name
Unconventional myosin-Va

Ligandability

Cysteine 788 of Unconventional myosin-Va

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1259 of Unconventional myosin-Va

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1259 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Unconventional myosin-Va between cysteines 1768 and 1771 (1766 and 1769 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5jcz
Structure name
rab11 bound to myova-gtd
Structure deposition date
2016-04-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
64
Peptide accession
Q9Y4I1
Residue number A
1768
Residue number B
1771
Peptide name
Unconventional myosin-Va

Ligandability

Cysteine 1768 of Unconventional myosin-Va

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1771 of Unconventional myosin-Va

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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