ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta/gamma crystallin domain-containing protein 1

Intramolecular
Cysteine 1448 and cysteine 1483
Cysteine 1477 and cysteine 1483
Cysteine 1448 and cysteine 1477
A redox-regulated disulphide may form within Beta/gamma crystallin domain-containing protein 1 between cysteines 1448 and 1483 (40 and 75 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2dad
Structure name
solution structure of the fifth crystall domain of the non-lens protein, absent in melanoma 1
Structure deposition date
2005-12-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
60
Peptide accession
Q9Y4K1
Residue number A
1448
Residue number B
1483
Peptide name
Beta/gamma crystallin domain-containing protein 1

Ligandability

Cysteine 1448 of Beta/gamma crystallin domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1483 of Beta/gamma crystallin domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta/gamma crystallin domain-containing protein 1 between cysteines 1477 and 1483 (69 and 75 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2dad
Structure name
solution structure of the fifth crystall domain of the non-lens protein, absent in melanoma 1
Structure deposition date
2005-12-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
20
Peptide accession
Q9Y4K1
Residue number A
1477
Residue number B
1483
Peptide name
Beta/gamma crystallin domain-containing protein 1

Ligandability

Cysteine 1477 of Beta/gamma crystallin domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1483 of Beta/gamma crystallin domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta/gamma crystallin domain-containing protein 1 between cysteines 1448 and 1477 (40 and 69 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2dad
Structure name
solution structure of the fifth crystall domain of the non-lens protein, absent in melanoma 1
Structure deposition date
2005-12-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
39
Peptide accession
Q9Y4K1
Residue number A
1448
Residue number B
1477
Peptide name
Beta/gamma crystallin domain-containing protein 1

Ligandability

Cysteine 1448 of Beta/gamma crystallin domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1477 of Beta/gamma crystallin domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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