TNF receptor-associated factor 6
Intermolecular
Cysteine 98 of TNF receptor-associated factor 5 and cysteine 85
Intramolecular
Cysteine 162 and cysteine 73
Cysteine 70 and cysteine 73
Cysteine 162 and cysteine 182
Cysteine 139 and cysteine 155
Cysteine 162 and cysteine 165
Cysteine 85 and cysteine 105
Cysteine 192 and cysteine 208
Cysteine 134 and cysteine 155
Cysteine 189 and cysteine 208
More...Cysteine 165 and cysteine 182
Cysteine 134 and cysteine 139
Cysteine 189 and cysteine 192
Cysteine 70 and cysteine 93
Cysteine 70 and cysteine 90
Cysteine 162 and cysteine 155
Cysteine 73 and cysteine 93
Cysteine 73 and cysteine 155
Cysteine 90 and cysteine 93
Cysteine 70 and cysteine 105
Cysteine 73 and cysteine 90
Cysteine 390 and cysteine 497
7l3l C 98 D 85
A redox-regulated disulphide may form between cysteine 98 of TNF receptor-associated factor 5 and cysteine 85 of TNF receptor-associated factor 6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
5
% buried
67
Peptide A name
TNF receptor-associated factor 5
Peptide B name
TNF receptor-associated factor 6
Peptide A accession
O00463
Peptide B accession
Q9Y4K3
Peptide A residue number
98
Peptide B residue number
85
Ligandability
Cysteine 98 of TNF receptor-associated factor 5
Cysteine 85 of TNF receptor-associated factor 6
7l3l D 134 D 139
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 162 and 73 (134 and 139 respectively in this structure).
Details
Redox score ?
93
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
0
Peptide accession
Q9Y4K3
Residue number A
162
Residue number B
73
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 162 of TNF receptor-associated factor 6
Cysteine 73 of TNF receptor-associated factor 6
7l3l D 70 D 73
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 70 and 73.
Details
Redox score ?
91
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
3
% buried
34
Peptide accession
Q9Y4K3
Residue number A
70
Residue number B
73
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 70 of TNF receptor-associated factor 6
Cysteine 73 of TNF receptor-associated factor 6
3hcs A 162 A 182
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 162 and 182.
Details
Redox score ?
88
PDB code
3hcs
Structure name
crystal structure of the n-terminal domain of traf6
Structure deposition date
2009-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
0
Peptide accession
Q9Y4K3
Residue number A
162
Residue number B
182
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 162 of TNF receptor-associated factor 6
Cysteine 182 of TNF receptor-associated factor 6
3hcs A 139 A 155
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 139 and 155.
Details
Redox score ?
88
PDB code
3hcs
Structure name
crystal structure of the n-terminal domain of traf6
Structure deposition date
2009-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
2
Peptide accession
Q9Y4K3
Residue number A
139
Residue number B
155
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 139 of TNF receptor-associated factor 6
Cysteine 155 of TNF receptor-associated factor 6
8hz2 A 162 A 165
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 162 and 165.
Details
Redox score ?
86
PDB code
8hz2
Structure name
tumor necrosis factor receptor associated factor 6 (traf6) n-terminal domain
Structure deposition date
2023-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
7
% buried
0
Peptide accession
Q9Y4K3
Residue number A
162
Residue number B
165
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 162 of TNF receptor-associated factor 6
Cysteine 165 of TNF receptor-associated factor 6
7l3l D 85 D 105
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 85 and 105.
Details
Redox score ?
85
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
5
% buried
47
Peptide accession
Q9Y4K3
Residue number A
85
Residue number B
105
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 85 of TNF receptor-associated factor 6
Cysteine 105 of TNF receptor-associated factor 6
8hz2 A 192 A 208
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 192 and 208.
Details
Redox score ?
85
PDB code
8hz2
Structure name
tumor necrosis factor receptor associated factor 6 (traf6) n-terminal domain
Structure deposition date
2023-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
8
% buried
0
Peptide accession
Q9Y4K3
Residue number A
192
Residue number B
208
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 192 of TNF receptor-associated factor 6
Cysteine 208 of TNF receptor-associated factor 6
8hz2 B 134 B 155
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 134 and 155.
Details
Redox score ?
85
PDB code
8hz2
Structure name
tumor necrosis factor receptor associated factor 6 (traf6) n-terminal domain
Structure deposition date
2023-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
12
Peptide accession
Q9Y4K3
Residue number A
134
Residue number B
155
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 134 of TNF receptor-associated factor 6
Cysteine 155 of TNF receptor-associated factor 6
8hz2 B 189 B 208
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 189 and 208.
Details
Redox score ?
84
PDB code
8hz2
Structure name
tumor necrosis factor receptor associated factor 6 (traf6) n-terminal domain
Structure deposition date
2023-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide accession
Q9Y4K3
Residue number A
189
Residue number B
208
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 189 of TNF receptor-associated factor 6
Cysteine 208 of TNF receptor-associated factor 6
3hcs A 165 A 182
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 165 and 182.
Details
Redox score ?
84
PDB code
3hcs
Structure name
crystal structure of the n-terminal domain of traf6
Structure deposition date
2009-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
0
Peptide accession
Q9Y4K3
Residue number A
165
Residue number B
182
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 165 of TNF receptor-associated factor 6
Cysteine 182 of TNF receptor-associated factor 6
8hz2 A 134 A 139
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 134 and 139.
Details
Redox score ?
84
PDB code
8hz2
Structure name
tumor necrosis factor receptor associated factor 6 (traf6) n-terminal domain
Structure deposition date
2023-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
8
Peptide accession
Q9Y4K3
Residue number A
134
Residue number B
139
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 134 of TNF receptor-associated factor 6
Cysteine 139 of TNF receptor-associated factor 6
8hz2 A 189 A 192
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 189 and 192.
Details
Redox score ?
83
PDB code
8hz2
Structure name
tumor necrosis factor receptor associated factor 6 (traf6) n-terminal domain
Structure deposition date
2023-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
8
% buried
0
Peptide accession
Q9Y4K3
Residue number A
189
Residue number B
192
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 189 of TNF receptor-associated factor 6
Cysteine 192 of TNF receptor-associated factor 6
3hcu C 70 C 93
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 70 and 93.
Details
Redox score ?
81
PDB code
3hcu
Structure name
crystal structure of traf6 in complex with ubc13 in the c2 space group
Structure deposition date
2009-05-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
76
Minimum pKa ?
6
% buried
84
Peptide accession
Q9Y4K3
Residue number A
70
Residue number B
93
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 70 of TNF receptor-associated factor 6
Cysteine 93 of TNF receptor-associated factor 6
3hcu C 70 C 90
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 70 and 90.
Details
Redox score ?
81
PDB code
3hcu
Structure name
crystal structure of traf6 in complex with ubc13 in the c2 space group
Structure deposition date
2009-05-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
73
Minimum pKa ?
6
% buried
83
Peptide accession
Q9Y4K3
Residue number A
70
Residue number B
90
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 70 of TNF receptor-associated factor 6
Cysteine 90 of TNF receptor-associated factor 6
7l3l D 134 D 155
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 162 and 155 (134 and 155 respectively in this structure).
Details
Redox score ?
67
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
0
Peptide accession
Q9Y4K3
Residue number A
162
Residue number B
155
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 162 of TNF receptor-associated factor 6
Cysteine 155 of TNF receptor-associated factor 6
3hcu C 73 C 93
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 73 and 93.
Details
Redox score ?
62
PDB code
3hcu
Structure name
crystal structure of traf6 in complex with ubc13 in the c2 space group
Structure deposition date
2009-05-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
77
Minimum pKa ?
15
% buried
nan
Peptide accession
Q9Y4K3
Residue number A
73
Residue number B
93
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 73 of TNF receptor-associated factor 6
Cysteine 93 of TNF receptor-associated factor 6
7l3l D 139 D 155
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 73 and 155 (139 and 155 respectively in this structure).
Details
Redox score ?
61
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q9Y4K3
Residue number A
73
Residue number B
155
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 73 of TNF receptor-associated factor 6
Cysteine 155 of TNF receptor-associated factor 6
3hcu C 90 C 93
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 90 and 93. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
3hcu
Structure name
crystal structure of traf6 in complex with ubc13 in the c2 space group
Structure deposition date
2009-05-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
15
% buried
76
Peptide accession
Q9Y4K3
Residue number A
90
Residue number B
93
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 90 of TNF receptor-associated factor 6
Cysteine 93 of TNF receptor-associated factor 6
2jmd A 9 A 44
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 70 and 105 (9 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
2jmd
Structure name
solution structure of the ring domain of human traf6
Structure deposition date
2006-11-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
19
Peptide accession
Q9Y4K3
Residue number A
70
Residue number B
105
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 70 of TNF receptor-associated factor 6
Cysteine 105 of TNF receptor-associated factor 6
3hcu A 73 A 90
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 73 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
3hcu
Structure name
crystal structure of traf6 in complex with ubc13 in the c2 space group
Structure deposition date
2009-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
22
% buried
nan
Peptide accession
Q9Y4K3
Residue number A
73
Residue number B
90
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 73 of TNF receptor-associated factor 6
Cysteine 90 of TNF receptor-associated factor 6
6a33 A 390 A 497
A redox-regulated disulphide may form within TNF receptor-associated factor 6 between cysteines 390 and 497. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
6a33
Structure name
binding and enhanced binding between key immunity proteins traf6 and tifa
Structure deposition date
2018-06-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
84
Peptide accession
Q9Y4K3
Residue number A
390
Residue number B
497
Peptide name
TNF receptor-associated factor 6
Ligandability
Cysteine 390 of TNF receptor-associated factor 6
Cysteine 497 of TNF receptor-associated factor 6
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