ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cysteine protease ATG4B

Intramolecular
Cysteine 74 and cysteine 78 L
Cysteine 301 and cysteine 306
Cysteine 323 and cysteine 333
Cysteine 183 and cysteine 323
A redox-regulated disulphide may form within Cysteine protease ATG4B between cysteines 74 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2cy7
Structure name
the crystal structure of human atg4b
Structure deposition date
2005-07-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
99
Minimum pKa ?
9
% buried
94
Peptide accession
Q9Y4P1
Residue number A
74
Residue number B
78
Peptide name
Cysteine protease ATG4B

Ligandability

Cysteine 74 of Cysteine protease ATG4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Cysteine protease ATG4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cysteine protease ATG4B between cysteines 301 and 306. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2d1i
Structure name
structure of human atg4b
Structure deposition date
2005-08-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
81
Peptide accession
Q9Y4P1
Residue number A
301
Residue number B
306
Peptide name
Cysteine protease ATG4B

Ligandability

Cysteine 301 of Cysteine protease ATG4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Cysteine protease ATG4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cysteine protease ATG4B between cysteines 323 and 333. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2d1i
Structure name
structure of human atg4b
Structure deposition date
2005-08-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
82
Peptide accession
Q9Y4P1
Residue number A
323
Residue number B
333
Peptide name
Cysteine protease ATG4B

Ligandability

Cysteine 323 of Cysteine protease ATG4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Cysteine protease ATG4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cysteine protease ATG4B between cysteines 183 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2d1i
Structure name
structure of human atg4b
Structure deposition date
2005-08-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
85
Peptide accession
Q9Y4P1
Residue number A
183
Residue number B
323
Peptide name
Cysteine protease ATG4B

Ligandability

Cysteine 183 of Cysteine protease ATG4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Cysteine protease ATG4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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