ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Intramolecular
Cysteine 114 and cysteine 144
Cysteine 52 and cysteine 84 L
Cysteine 234 and cysteine 316
Cysteine 84 and cysteine 93
A redox-regulated disulphide may form within Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2 between cysteines 114 and 144.

Details

Redox score ?
69
PDB code
7f69
Structure name
crystal structure of wipi2b in complex with atg16l1
Structure deposition date
2021-06-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
7
% buried
88
Peptide accession
Q9Y4P8-2
Residue number A
114
Residue number B
144
Peptide name
Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Ligandability

Cysteine 114 of Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2 between cysteines 52 and 84. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7f69
Structure name
crystal structure of wipi2b in complex with atg16l1
Structure deposition date
2021-06-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
56
Peptide accession
Q9Y4P8-2
Residue number A
52
Residue number B
84
Peptide name
Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Ligandability

Cysteine 52 of Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2 between cysteines 234 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7f69
Structure name
crystal structure of wipi2b in complex with atg16l1
Structure deposition date
2021-06-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
86
Peptide accession
Q9Y4P8-2
Residue number A
234
Residue number B
316
Peptide name
Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Ligandability

Cysteine 234 of Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2 between cysteines 84 and 93. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7f69
Structure name
crystal structure of wipi2b in complex with atg16l1
Structure deposition date
2021-06-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
72
Peptide accession
Q9Y4P8-2
Residue number A
84
Residue number B
93
Peptide name
Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Ligandability

Cysteine 84 of Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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