ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA-directed RNA polymerase III subunit RPC8

Intramolecular
Cysteine 45 and cysteine 47
Cysteine 47 and cysteine 74
Cysteine 45 and cysteine 74
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC8 between cysteines 45 and 47. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
8
% buried
100
Peptide accession
Q9Y535
Residue number A
45
Residue number B
47
Peptide name
DNA-directed RNA polymerase III subunit RPC8

Ligandability

Cysteine 45 of DNA-directed RNA polymerase III subunit RPC8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of DNA-directed RNA polymerase III subunit RPC8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC8 between cysteines 47 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7d59
Structure name
cryo-em structure of human rna polymerase iii in apo state
Structure deposition date
2020-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
98
Peptide accession
Q9Y535
Residue number A
47
Residue number B
74
Peptide name
DNA-directed RNA polymerase III subunit RPC8

Ligandability

Cysteine 47 of DNA-directed RNA polymerase III subunit RPC8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of DNA-directed RNA polymerase III subunit RPC8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC8 between cysteines 45 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
89
Peptide accession
Q9Y535
Residue number A
45
Residue number B
74
Peptide name
DNA-directed RNA polymerase III subunit RPC8

Ligandability

Cysteine 45 of DNA-directed RNA polymerase III subunit RPC8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of DNA-directed RNA polymerase III subunit RPC8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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