ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-interacting serine/threonine-protein kinase 3

Intermolecular
Cysteine 234 and cysteine 234 L
Cysteine 455 and cysteine 455
Intramolecular
Cysteine 265 and cysteine 279
Cysteine 130 and cysteine 284
A redox-regulated disulphide may form between two units of Receptor-interacting serine/threonine-protein kinase 3 at cysteines 234 and 234.

Details

Redox score ?
82
PDB code
7mx3
Structure name
crystal structure of human ripk3 complexed with gsk'843
Structure deposition date
2021-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide A name
Receptor-interacting serine/threonine-protein kinase 3
Peptide B name
Receptor-interacting serine/threonine-protein kinase 3
Peptide A accession
Q9Y572
Peptide B accession
Q9Y572
Peptide A residue number
234
Peptide B residue number
234

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Receptor-interacting serine/threonine-protein kinase 3 at cysteines 455 and 455 (9 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7dac
Structure name
human ripk3 amyloid fibril revealed by solid-state nmr
Structure deposition date
2020-10-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
76
Peptide A name
Receptor-interacting serine/threonine-protein kinase 3
Peptide B name
Receptor-interacting serine/threonine-protein kinase 3
Peptide A accession
Q9Y572
Peptide B accession
Q9Y572
Peptide A residue number
455
Peptide B residue number
455

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-interacting serine/threonine-protein kinase 3 between cysteines 265 and 279.

Details

Redox score ?
72
PDB code
7mon
Structure name
structure of human ripk3-mlkl complex
Structure deposition date
2021-05-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
86
Peptide accession
Q9Y572
Residue number A
265
Residue number B
279
Peptide name
Receptor-interacting serine/threonine-protein kinase 3

Ligandability

Cysteine 265 of Receptor-interacting serine/threonine-protein kinase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Receptor-interacting serine/threonine-protein kinase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-interacting serine/threonine-protein kinase 3 between cysteines 130 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4m66
Structure name
crystal structure of the mouse rip3 kinase domain
Structure deposition date
2013-08-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
84
Peptide accession
Q9QZL0
Residue number A
130
Residue number B
284
Peptide name
Receptor-interacting serine/threonine-protein kinase 3

Ligandability

Cysteine 130 of Receptor-interacting serine/threonine-protein kinase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Receptor-interacting serine/threonine-protein kinase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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