ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitochondrial import inner membrane translocase subunit Tim22

Intramolecular
Cysteine 69 and cysteine 141
Cysteine 160 and cysteine 179
Cysteine 69 and cysteine 138
Cysteine 138 and cysteine 141
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim22 between cysteines 69 and 141.

Details

Redox score ?
84
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y584
Residue number A
69
Residue number B
141
Peptide name
Mitochondrial import inner membrane translocase subunit Tim22

Ligandability

Cysteine 69 of Mitochondrial import inner membrane translocase subunit Tim22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Mitochondrial import inner membrane translocase subunit Tim22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim22 between cysteines 160 and 179.

Details

Redox score ?
83
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y584
Residue number A
160
Residue number B
179
Peptide name
Mitochondrial import inner membrane translocase subunit Tim22

Ligandability

Cysteine 160 of Mitochondrial import inner membrane translocase subunit Tim22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Mitochondrial import inner membrane translocase subunit Tim22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim22 between cysteines 69 and 138.

Details

Redox score ?
65
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9Y584
Residue number A
69
Residue number B
138
Peptide name
Mitochondrial import inner membrane translocase subunit Tim22

Ligandability

Cysteine 69 of Mitochondrial import inner membrane translocase subunit Tim22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Mitochondrial import inner membrane translocase subunit Tim22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim22 between cysteines 138 and 141. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9Y584
Residue number A
138
Residue number B
141
Peptide name
Mitochondrial import inner membrane translocase subunit Tim22

Ligandability

Cysteine 138 of Mitochondrial import inner membrane translocase subunit Tim22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Mitochondrial import inner membrane translocase subunit Tim22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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