Mitochondrial import inner membrane translocase subunit Tim10 B
Intramolecular
Cysteine 32 and cysteine 48
Cysteine 28 and cysteine 52
Cysteine 32 and cysteine 52
Cysteine 28 and cysteine 32
Cysteine 48 and cysteine 52
Cysteine 28 and cysteine 48
7cgp J 32 J 48
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 B between cysteines 32 and 48.
Details
Redox score ?
81
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J6
Residue number A
32
Residue number B
48
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10 B
Ligandability
Cysteine 32 of Mitochondrial import inner membrane translocase subunit Tim10 B
Cysteine 48 of Mitochondrial import inner membrane translocase subunit Tim10 B
7cgp J 28 J 52
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 B between cysteines 28 and 52.
Details
Redox score ?
79
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J6
Residue number A
28
Residue number B
52
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10 B
Ligandability
Cysteine 28 of Mitochondrial import inner membrane translocase subunit Tim10 B
Cysteine 52 of Mitochondrial import inner membrane translocase subunit Tim10 B
7cgp J 32 J 52
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 B between cysteines 32 and 52.
Details
Redox score ?
65
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J6
Residue number A
32
Residue number B
52
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10 B
Ligandability
Cysteine 32 of Mitochondrial import inner membrane translocase subunit Tim10 B
Cysteine 52 of Mitochondrial import inner membrane translocase subunit Tim10 B
7cgp J 28 J 32
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 B between cysteines 28 and 32.
Details
Redox score ?
60
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J6
Residue number A
28
Residue number B
32
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10 B
Ligandability
Cysteine 28 of Mitochondrial import inner membrane translocase subunit Tim10 B
Cysteine 32 of Mitochondrial import inner membrane translocase subunit Tim10 B
7cgp J 48 J 52
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 B between cysteines 48 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J6
Residue number A
48
Residue number B
52
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10 B
Ligandability
Cysteine 48 of Mitochondrial import inner membrane translocase subunit Tim10 B
Cysteine 52 of Mitochondrial import inner membrane translocase subunit Tim10 B
7cgp J 28 J 48
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim10 B between cysteines 28 and 48. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7cgp
Structure name
cryo-em structure of the human mitochondrial translocase tim22 complex at 3
Structure deposition date
2020-07-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J6
Residue number A
28
Residue number B
48
Peptide name
Mitochondrial import inner membrane translocase subunit Tim10 B
Ligandability
Cysteine 28 of Mitochondrial import inner membrane translocase subunit Tim10 B
Cysteine 48 of Mitochondrial import inner membrane translocase subunit Tim10 B
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