ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Mitochondrial import inner membrane translocase subunit Tim9

Intramolecular
Cysteine 32 and cysteine 48
Cysteine 28 and cysteine 52
Cysteine 32 and cysteine 52
Cysteine 28 and cysteine 32
Cysteine 48 and cysteine 52
Cysteine 28 and cysteine 48
A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim9 between cysteines 32 and 48.

Details

Redox score ?
82
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J7
Residue number A
32
Residue number B
48
Peptide name
Mitochondrial import inner membrane translocase subunit Tim9

Ligandability

Cysteine 32 of Mitochondrial import inner membrane translocase subunit Tim9

Cysteine 48 of Mitochondrial import inner membrane translocase subunit Tim9

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim9 between cysteines 28 and 52.

Details

Redox score ?
81
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J7
Residue number A
28
Residue number B
52
Peptide name
Mitochondrial import inner membrane translocase subunit Tim9

Ligandability

Cysteine 28 of Mitochondrial import inner membrane translocase subunit Tim9

Cysteine 52 of Mitochondrial import inner membrane translocase subunit Tim9

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim9 between cysteines 32 and 52.

Details

Redox score ?
66
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J7
Residue number A
32
Residue number B
52
Peptide name
Mitochondrial import inner membrane translocase subunit Tim9

Ligandability

Cysteine 32 of Mitochondrial import inner membrane translocase subunit Tim9

Cysteine 52 of Mitochondrial import inner membrane translocase subunit Tim9

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim9 between cysteines 28 and 32. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J7
Residue number A
28
Residue number B
32
Peptide name
Mitochondrial import inner membrane translocase subunit Tim9

Ligandability

Cysteine 28 of Mitochondrial import inner membrane translocase subunit Tim9

Cysteine 32 of Mitochondrial import inner membrane translocase subunit Tim9

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim9 between cysteines 48 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J7
Residue number A
48
Residue number B
52
Peptide name
Mitochondrial import inner membrane translocase subunit Tim9

Ligandability

Cysteine 48 of Mitochondrial import inner membrane translocase subunit Tim9

Cysteine 52 of Mitochondrial import inner membrane translocase subunit Tim9

A redox-regulated disulphide may form within Mitochondrial import inner membrane translocase subunit Tim9 between cysteines 28 and 48. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
2bsk
Structure name
crystal structure of the tim9 tim10 hexameric complex
Structure deposition date
2005-05-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y5J7
Residue number A
28
Residue number B
48
Peptide name
Mitochondrial import inner membrane translocase subunit Tim9

Ligandability

Cysteine 28 of Mitochondrial import inner membrane translocase subunit Tim9

Cysteine 48 of Mitochondrial import inner membrane translocase subunit Tim9

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