ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ubiquitin carboxyl-terminal hydrolase isozyme L5

Intramolecular
Cysteine 27 and cysteine 100
Cysteine 9 and cysteine 88
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase isozyme L5 between cysteines 27 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3ris
Structure name
crystal structure of the catalytic domain of uchl5, a proteasome- associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme
Structure deposition date
2011-04-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
80
Peptide accession
Q9Y5K5
Residue number A
27
Residue number B
100
Peptide name
Ubiquitin carboxyl-terminal hydrolase isozyme L5

Ligandability

Cysteine 27 of Ubiquitin carboxyl-terminal hydrolase isozyme L5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Ubiquitin carboxyl-terminal hydrolase isozyme L5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase isozyme L5 between cysteines 9 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4uf6
Structure name
uch-l5 in complex with ubiquitin-propargyl bound to an activating fragment of ino80g
Structure deposition date
2014-12-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
83
Peptide accession
Q9Y5K5
Residue number A
9
Residue number B
88
Peptide name
Ubiquitin carboxyl-terminal hydrolase isozyme L5

Ligandability

Cysteine 9 of Ubiquitin carboxyl-terminal hydrolase isozyme L5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Ubiquitin carboxyl-terminal hydrolase isozyme L5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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