ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Methyltransferase N6AMT1

Intramolecular
Cysteine 85 and cysteine 92
Cysteine 49 and cysteine 75
A redox-regulated disulphide may form within Methyltransferase N6AMT1 between cysteines 85 and 92. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6k0x
Structure name
structure of n6amt1-trmt112 complex with sam
Structure deposition date
2019-05-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
18
Peptide accession
Q9Y5N5
Residue number A
85
Residue number B
92
Peptide name
Methyltransferase N6AMT1

Ligandability

Cysteine 85 of Methyltransferase N6AMT1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Methyltransferase N6AMT1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methyltransferase N6AMT1 between cysteines 49 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6khs
Structure name
crystal structure of hemk2/trmt112 in complex with sah and meq
Structure deposition date
2019-07-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Y5N5
Residue number A
49
Residue number B
75
Peptide name
Methyltransferase N6AMT1

Ligandability

Cysteine 49 of Methyltransferase N6AMT1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Methyltransferase N6AMT1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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