ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Origin recognition complex subunit 6

Intramolecular
Cysteine 107 and cysteine 149
Cysteine 35 and cysteine 82 L
Cysteine 35 and cysteine 51 L
Cysteine 35 and cysteine 88 L
Cysteine 149 and cysteine 176
Cysteine 51 and cysteine 82 L
A redox-regulated disulphide may form within Origin recognition complex subunit 6 between cysteines 107 and 149.

Details

Redox score ?
83
PDB code
3m03
Structure name
crystal structure of human orc6 fragment
Structure deposition date
2010-03-02
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
32
Peptide accession
Q9Y5N6
Residue number A
107
Residue number B
149
Peptide name
Origin recognition complex subunit 6

Ligandability

Cysteine 107 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 6 between cysteines 35 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6kvg
Structure name
the solution structure of human orc6
Structure deposition date
2019-09-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
28
Peptide accession
Q9Y5N6
Residue number A
35
Residue number B
82
Peptide name
Origin recognition complex subunit 6

Ligandability

Cysteine 35 of Origin recognition complex subunit 6

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 6 between cysteines 35 and 51. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6kvg
Structure name
the solution structure of human orc6
Structure deposition date
2019-09-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
64
Peptide accession
Q9Y5N6
Residue number A
35
Residue number B
51
Peptide name
Origin recognition complex subunit 6

Ligandability

Cysteine 35 of Origin recognition complex subunit 6

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 6 between cysteines 35 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6kvg
Structure name
the solution structure of human orc6
Structure deposition date
2019-09-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
22
Peptide accession
Q9Y5N6
Residue number A
35
Residue number B
88
Peptide name
Origin recognition complex subunit 6

Ligandability

Cysteine 35 of Origin recognition complex subunit 6

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 6 between cysteines 149 and 176. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
3m03
Structure name
crystal structure of human orc6 fragment
Structure deposition date
2010-03-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
60
Peptide accession
Q9Y5N6
Residue number A
149
Residue number B
176
Peptide name
Origin recognition complex subunit 6

Ligandability

Cysteine 149 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 6 between cysteines 51 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6kvg
Structure name
the solution structure of human orc6
Structure deposition date
2019-09-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
62
Peptide accession
Q9Y5N6
Residue number A
51
Residue number B
82
Peptide name
Origin recognition complex subunit 6

Ligandability

Cysteine 51 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Origin recognition complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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