Ceramide transfer protein
Intermolecular
Cysteine 27 and cysteine 27
Cysteine 65 and cysteine 27
Intramolecular
Cysteine 459 and cysteine 555
Cysteine 555 and cysteine 575
Cysteine 459 and cysteine 575
Cysteine 459 and cysteine 529
4hhv A 27 B 27
A redox-regulated disulphide may form between two units of Ceramide transfer protein at cysteines 27 and 27. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
4hhv
Structure name
crystal structure of ceramide transfer protein pleckstrin homology domain
Structure deposition date
2012-10-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
94
Peptide A name
Ceramide transfer protein
Peptide B name
Ceramide transfer protein
Peptide A accession
Q9Y5P4
Peptide B accession
Q9Y5P4
Peptide A residue number
27
Peptide B residue number
27
Ligandability
4hhv A 65 B 27
A redox-regulated disulphide may form between two units of Ceramide transfer protein at cysteines 65 and 27. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4hhv
Structure name
crystal structure of ceramide transfer protein pleckstrin homology domain
Structure deposition date
2012-10-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
68
Peptide A name
Ceramide transfer protein
Peptide B name
Ceramide transfer protein
Peptide A accession
Q9Y5P4
Peptide B accession
Q9Y5P4
Peptide A residue number
65
Peptide B residue number
27
Ligandability
Cysteine 65 of Ceramide transfer protein
Cysteine 27 of Ceramide transfer protein
3h3t B 433 B 529
A redox-regulated disulphide may form within Ceramide transfer protein between cysteines 459 and 555 (433 and 529 respectively in this structure).
Details
Redox score ?
67
PDB code
3h3t
Structure name
crystal structure of the cert start domain in complex with hpa-16
Structure deposition date
2009-04-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
100
Peptide accession
A8K7S2
Residue number A
459
Residue number B
555
Peptide name
Ceramide transfer protein
Ligandability
Cysteine 459 of Ceramide transfer protein
Cysteine 555 of Ceramide transfer protein
6j81 A 529 A 549
A redox-regulated disulphide may form within Ceramide transfer protein between cysteines 555 and 575 (529 and 549 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6j81
Structure name
crystal structure of cert start domain in complex with compound e14
Structure deposition date
2019-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
15
% buried
98
Peptide accession
Q9Y5P4
Residue number A
555
Residue number B
575
Peptide name
Ceramide transfer protein
Ligandability
Cysteine 555 of Ceramide transfer protein
Cysteine 575 of Ceramide transfer protein
5jjd B 433 B 549
A redox-regulated disulphide may form within Ceramide transfer protein between cysteines 459 and 575 (433 and 549 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
5jjd
Structure name
crystal structure of the ceramide transfer protein ph and start domain complex
Structure deposition date
2016-04-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
100
Peptide accession
Q9Y5P4
Residue number A
459
Residue number B
575
Peptide name
Ceramide transfer protein
Ligandability
Cysteine 459 of Ceramide transfer protein
Cysteine 575 of Ceramide transfer protein
2e3q A 433 A 503
A redox-regulated disulphide may form within Ceramide transfer protein between cysteines 459 and 529 (433 and 503 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
2e3q
Structure name
crystal structure of cert start domain in complex with c18- ceramide (p212121)
Structure deposition date
2006-11-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
100
Peptide accession
Q53YV2
Residue number A
459
Residue number B
529
Peptide name
Ceramide transfer protein
Ligandability
Cysteine 459 of Ceramide transfer protein
Cysteine 529 of Ceramide transfer protein
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