ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mannose-1-phosphate guanyltransferase beta

Intramolecular
Cysteine 289 and cysteine 306
Cysteine 266 and cysteine 285
Cysteine 306 and cysteine 312
Cysteine 285 and cysteine 289
Cysteine 29 and cysteine 230
Cysteine 289 and cysteine 312
Cysteine 230 and cysteine 289
Cysteine 285 and cysteine 306
A redox-regulated disulphide may form within Mannose-1-phosphate guanyltransferase beta between cysteines 289 and 306.

Details

Redox score ?
64
PDB code
7d74
Structure name
cryo-em structure of gmppa/gmppb complex bound to gtp (state ii)
Structure deposition date
2020-10-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
100
Peptide accession
Q9Y5P6
Residue number A
289
Residue number B
306
Peptide name
Mannose-1-phosphate guanyltransferase beta

Ligandability

Cysteine 289 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-1-phosphate guanyltransferase beta between cysteines 266 and 285. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7d74
Structure name
cryo-em structure of gmppa/gmppb complex bound to gtp (state ii)
Structure deposition date
2020-10-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
76
Peptide accession
Q9Y5P6
Residue number A
266
Residue number B
285
Peptide name
Mannose-1-phosphate guanyltransferase beta

Ligandability

Cysteine 266 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 285 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-1-phosphate guanyltransferase beta between cysteines 306 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7d73
Structure name
cryo-em structure of gmppa/gmppb complex bound to gtp (state i)
Structure deposition date
2020-10-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y5P6
Residue number A
306
Residue number B
312
Peptide name
Mannose-1-phosphate guanyltransferase beta

Ligandability

Cysteine 306 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-1-phosphate guanyltransferase beta between cysteines 285 and 289. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7d73
Structure name
cryo-em structure of gmppa/gmppb complex bound to gtp (state i)
Structure deposition date
2020-10-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
95
Peptide accession
Q9Y5P6
Residue number A
285
Residue number B
289
Peptide name
Mannose-1-phosphate guanyltransferase beta

Ligandability

Cysteine 285 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 289 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-1-phosphate guanyltransferase beta between cysteines 29 and 230. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7d72
Structure name
cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose
Structure deposition date
2020-10-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
70
Peptide accession
Q9Y5P6
Residue number A
29
Residue number B
230
Peptide name
Mannose-1-phosphate guanyltransferase beta

Ligandability

Cysteine 29 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-1-phosphate guanyltransferase beta between cysteines 289 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7d72
Structure name
cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose
Structure deposition date
2020-10-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
9
% buried
100
Peptide accession
Q9Y5P6
Residue number A
289
Residue number B
312
Peptide name
Mannose-1-phosphate guanyltransferase beta

Ligandability

Cysteine 289 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-1-phosphate guanyltransferase beta between cysteines 230 and 289. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7d73
Structure name
cryo-em structure of gmppa/gmppb complex bound to gtp (state i)
Structure deposition date
2020-10-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
9
% buried
80
Peptide accession
Q9Y5P6
Residue number A
230
Residue number B
289
Peptide name
Mannose-1-phosphate guanyltransferase beta

Ligandability

Cysteine 230 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 289 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-1-phosphate guanyltransferase beta between cysteines 285 and 306. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
7d74
Structure name
cryo-em structure of gmppa/gmppb complex bound to gtp (state ii)
Structure deposition date
2020-10-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9Y5P6
Residue number A
285
Residue number B
306
Peptide name
Mannose-1-phosphate guanyltransferase beta

Ligandability

Cysteine 285 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Mannose-1-phosphate guanyltransferase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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