ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transient receptor potential cation channel subfamily V member 2

Intramolecular
Cysteine 195 and cysteine 206
Cysteine 157 and cysteine 206
Cysteine 135 and cysteine 179
Cysteine 206 and cysteine 219
Cysteine 115 and cysteine 130
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 2 between cysteines 195 and 206.

Details

Redox score ?
84
PDB code
2etc
Structure name
crystal structure of the ankyrin repeat domain of trpv2
Structure deposition date
2005-10-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9WUD2
Residue number A
195
Residue number B
206
Peptide name
Transient receptor potential cation channel subfamily V member 2

Ligandability

Cysteine 195 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 2 between cysteines 157 and 206. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2etc
Structure name
crystal structure of the ankyrin repeat domain of trpv2
Structure deposition date
2005-10-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9WUD2
Residue number A
157
Residue number B
206
Peptide name
Transient receptor potential cation channel subfamily V member 2

Ligandability

Cysteine 157 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 2 between cysteines 135 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6u88
Structure name
cbd-bound full-length rat trpv2 in nanodiscs, state 2
Structure deposition date
2019-09-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
54
Peptide accession
Q9WUD2
Residue number A
135
Residue number B
179
Peptide name
Transient receptor potential cation channel subfamily V member 2

Ligandability

Cysteine 135 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 2 between cysteines 206 and 219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6bo5
Structure name
trpv2 ion channel in partially closed state
Structure deposition date
2017-11-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
88
Peptide accession
Q9WUD2
Residue number A
206
Residue number B
219
Peptide name
Transient receptor potential cation channel subfamily V member 2

Ligandability

Cysteine 206 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 2 between cysteines 115 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7xeu
Structure name
structure of mtrpv2_e2
Structure deposition date
2022-03-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
76
Peptide accession
Q9WTR1
Residue number A
115
Residue number B
130
Peptide name
Transient receptor potential cation channel subfamily V member 2

Ligandability

Cysteine 115 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Transient receptor potential cation channel subfamily V member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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