a tool for identifying drug-targetable redox-active disulphides

Wnt inhibitory factor 1

Intramolecular

Cysteine 140 and cysteine 177

A redox-regulated disulphide may form within Wnt inhibitory factor 1 between cysteines 140 and 177 (116 and 153 respectively in this structure).

Details

Redox score ?

88

PDB code

Structure name

nmr structure of the wif domain from human wif-1

Structure deposition date

2005-09-29

Thiol separation (Å)

2

Half-sphere exposure sum ?

70

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

140

Residue number B

177

Peptide name

Wnt inhibitory factor 1

Ligandability

Cysteine 140 of Wnt inhibitory factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Wnt inhibitory factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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