a tool for identifying drug-targetable redox-active disulphides

Sorting nexin-11

Intermolecular

Cysteine 55 and cysteine 138

A redox-regulated disulphide may form between two units of Sorting nexin-11 at cysteines 55 and 138.

Details

Redox score ?

84

PDB code

Structure name

crystal structure of snx11-pxe domain in dimer form

Structure deposition date

2019-08-11

Thiol separation (Å)

2

Half-sphere exposure sum ?

75

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Sorting nexin-11

Peptide B name

Sorting nexin-11

Peptide A accession

Peptide B accession

Peptide A residue number

55

Peptide B residue number

138

Ligandability

Cysteine 55 of Sorting nexin-11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Sorting nexin-11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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