a tool for identifying drug-targetable redox-active disulphides

Host cell factor 2

Intramolecular

Cysteine 664 and cysteine 670

A redox-regulated disulphide may form within Host cell factor 2 between cysteines 664 and 670 (65 and 71 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

40

PDB code

Structure name

solution structure of c-terminal fibronectin type iii domain of mouse 1700129l13rik protein

Structure deposition date

2004-05-26

Thiol separation (Å)

10

Half-sphere exposure sum ?

52

Minimum pK_a ?

9

% buried

30

Peptide accession

Residue number A

664

Residue number B

670

Peptide name

Host cell factor 2

Ligandability

Cysteine 664 of Host cell factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 670 of Host cell factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: