ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cysteine sulfinic acid decarboxylase

Intramolecular
Cysteine 171 and cysteine 328
Cysteine 313 and cysteine 362
A redox-regulated disulphide may form within Cysteine sulfinic acid decarboxylase between cysteines 171 and 328. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7a0a
Structure name
crystal structure of mouse csad in apo form
Structure deposition date
2020-08-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
96
Peptide accession
Q9DBE0
Residue number A
171
Residue number B
328
Peptide name
Cysteine sulfinic acid decarboxylase

Ligandability

Cysteine 171 of Cysteine sulfinic acid decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Cysteine sulfinic acid decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cysteine sulfinic acid decarboxylase between cysteines 313 and 362. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2jis
Structure name
human cysteine sulfinic acid decarboxylase (csad) in complex with plp
Structure deposition date
2007-06-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Y600
Residue number A
313
Residue number B
362
Peptide name
Cysteine sulfinic acid decarboxylase

Ligandability

Cysteine 313 of Cysteine sulfinic acid decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 362 of Cysteine sulfinic acid decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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