ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pseudouridylate synthase 1 homolog

Intramolecular
Cysteine 142 and cysteine 196
Cysteine 202 and cysteine 268
A redox-regulated disulphide may form within Pseudouridylate synthase 1 homolog between cysteines 142 and 196.

Details

Redox score ?
74
PDB code
4iqm
Structure name
crystal structure of the catalytic domain of human pus1
Structure deposition date
2013-01-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
83
Peptide accession
Q9Y606
Residue number A
142
Residue number B
196
Peptide name
Pseudouridylate synthase 1 homolog

Ligandability

Cysteine 142 of Pseudouridylate synthase 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Pseudouridylate synthase 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudouridylate synthase 1 homolog between cysteines 202 and 268. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4nz7
Structure name
steroid receptor rna activator (sra) modification by the human pseudouridine synthase 1 (hpus1p): rna binding, activity, and atomic model
Structure deposition date
2013-12-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
91
Peptide accession
Q9Y606
Residue number A
202
Residue number B
268
Peptide name
Pseudouridylate synthase 1 homolog

Ligandability

Cysteine 202 of Pseudouridylate synthase 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of Pseudouridylate synthase 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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