ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Neuroplastin

Intramolecular
Cysteine 169 and cysteine 217
Cysteine 259 and cysteine 316
A redox-regulated disulphide may form within Neuroplastin between cysteines 169 and 217 (25 and 73 respectively in this structure).

Details

Redox score ?
82
PDB code
2wv3
Structure name
neuroplastin-55 binds to and signals through the fibroblast growth factor receptor
Structure deposition date
2009-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P97546
Residue number A
169
Residue number B
217
Peptide name
Neuroplastin

Ligandability

Cysteine 169 of Neuroplastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Neuroplastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuroplastin between cysteines 259 and 316 (143 and 200 respectively in this structure).

Details

Redox score ?
82
PDB code
6a69
Structure name
cryo-em structure of a p-type atpase
Structure deposition date
2018-06-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y639
Residue number A
259
Residue number B
316
Peptide name
Neuroplastin

Ligandability

Cysteine 259 of Neuroplastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Neuroplastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: