Adhesion G-protein coupled receptor G1
Intramolecular
Cysteine 366 and cysteine 379
Cysteine 475 and cysteine 562
Cysteine 346 and cysteine 377
Cysteine 35 and cysteine 91
Cysteine 121 and cysteine 177
Cysteine 377 and cysteine 379
Cysteine 346 and cysteine 379
Cysteine 346 and cysteine 366
Cysteine 366 and cysteine 377
Cysteine 418 and cysteine 489
5kvm A 366 A 379
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 366 and 379.
Details
Redox score ?
85
PDB code
5kvm
Structure name
extracellular region of mouse gpr56/adgrg1 in complex with fn3 monobody
Structure deposition date
2016-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K209
Residue number A
366
Residue number B
379
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 366 of Adhesion G-protein coupled receptor G1
Cysteine 379 of Adhesion G-protein coupled receptor G1
7sf8 A 469 A 556
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 475 and 562 (469 and 556 respectively in this structure).
Details
Redox score ?
83
PDB code
7sf8
Structure name
gpr56 (adgrg1) 7tm domain bound to tethered agonist in complex with g protein heterotrimer
Structure deposition date
2021-10-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y653
Residue number A
475
Residue number B
562
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 475 of Adhesion G-protein coupled receptor G1
Cysteine 562 of Adhesion G-protein coupled receptor G1
5kvm A 346 A 377
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 346 and 377.
Details
Redox score ?
81
PDB code
5kvm
Structure name
extracellular region of mouse gpr56/adgrg1 in complex with fn3 monobody
Structure deposition date
2016-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K209
Residue number A
346
Residue number B
377
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 346 of Adhesion G-protein coupled receptor G1
Cysteine 377 of Adhesion G-protein coupled receptor G1
5kvm A 35 A 91
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 35 and 91.
Details
Redox score ?
81
PDB code
5kvm
Structure name
extracellular region of mouse gpr56/adgrg1 in complex with fn3 monobody
Structure deposition date
2016-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K209
Residue number A
35
Residue number B
91
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 35 of Adhesion G-protein coupled receptor G1
Cysteine 91 of Adhesion G-protein coupled receptor G1
5kvm A 121 A 177
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 121 and 177.
Details
Redox score ?
80
PDB code
5kvm
Structure name
extracellular region of mouse gpr56/adgrg1 in complex with fn3 monobody
Structure deposition date
2016-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K209
Residue number A
121
Residue number B
177
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 121 of Adhesion G-protein coupled receptor G1
Cysteine 177 of Adhesion G-protein coupled receptor G1
5kvm A 377 A 379
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 377 and 379. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
5kvm
Structure name
extracellular region of mouse gpr56/adgrg1 in complex with fn3 monobody
Structure deposition date
2016-07-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K209
Residue number A
377
Residue number B
379
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 377 of Adhesion G-protein coupled receptor G1
Cysteine 379 of Adhesion G-protein coupled receptor G1
5kvm A 346 A 379
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 346 and 379. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
5kvm
Structure name
extracellular region of mouse gpr56/adgrg1 in complex with fn3 monobody
Structure deposition date
2016-07-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K209
Residue number A
346
Residue number B
379
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 346 of Adhesion G-protein coupled receptor G1
Cysteine 379 of Adhesion G-protein coupled receptor G1
5kvm A 346 A 366
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 346 and 366. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
5kvm
Structure name
extracellular region of mouse gpr56/adgrg1 in complex with fn3 monobody
Structure deposition date
2016-07-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K209
Residue number A
346
Residue number B
366
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 346 of Adhesion G-protein coupled receptor G1
Cysteine 366 of Adhesion G-protein coupled receptor G1
5kvm A 366 A 377
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 366 and 377. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5kvm
Structure name
extracellular region of mouse gpr56/adgrg1 in complex with fn3 monobody
Structure deposition date
2016-07-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K209
Residue number A
366
Residue number B
377
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 366 of Adhesion G-protein coupled receptor G1
Cysteine 377 of Adhesion G-protein coupled receptor G1
7sf8 A 418 A 483
A redox-regulated disulphide may form within Adhesion G-protein coupled receptor G1 between cysteines 418 and 489 (418 and 483 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7sf8
Structure name
gpr56 (adgrg1) 7tm domain bound to tethered agonist in complex with g protein heterotrimer
Structure deposition date
2021-10-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
90
Peptide accession
Q9Y653
Residue number A
418
Residue number B
489
Peptide name
Adhesion G-protein coupled receptor G1
Ligandability
Cysteine 418 of Adhesion G-protein coupled receptor G1
Cysteine 489 of Adhesion G-protein coupled receptor G1
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