Solute carrier family 12 member 7
Intramolecular
Cysteine 343 and cysteine 352
Cysteine 163 and cysteine 626
Cysteine 308 and cysteine 323
Cysteine 160 and cysteine 161
Cysteine 160 and cysteine 633
Cysteine 204 and cysteine 588
Cysteine 160 and cysteine 163
Cysteine 163 and cysteine 633
Cysteine 161 and cysteine 163
Cysteine 160 and cysteine 626
More...Cysteine 588 and cysteine 626
Cysteine 163 and cysteine 588
7d99 A 343 A 352
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 343 and 352.
Details
Redox score ?
89
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y666
Residue number A
343
Residue number B
352
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 343 of Solute carrier family 12 member 7
Cysteine 352 of Solute carrier family 12 member 7
7d99 B 163 B 626
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 163 and 626.
Details
Redox score ?
82
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y666
Residue number A
163
Residue number B
626
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 163 of Solute carrier family 12 member 7
Cysteine 626 of Solute carrier family 12 member 7
7d99 A 308 A 323
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 308 and 323.
Details
Redox score ?
81
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y666
Residue number A
308
Residue number B
323
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 308 of Solute carrier family 12 member 7
Cysteine 323 of Solute carrier family 12 member 7
7d99 A 160 A 161
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 160 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
92
Peptide accession
Q9Y666
Residue number A
160
Residue number B
161
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 160 of Solute carrier family 12 member 7
Cysteine 161 of Solute carrier family 12 member 7
7d99 B 160 B 633
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 160 and 633. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
96
Peptide accession
Q9Y666
Residue number A
160
Residue number B
633
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 160 of Solute carrier family 12 member 7
Cysteine 633 of Solute carrier family 12 member 7
7d99 A 204 A 588
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 204 and 588. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
96
Peptide accession
Q9Y666
Residue number A
204
Residue number B
588
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 204 of Solute carrier family 12 member 7
Cysteine 588 of Solute carrier family 12 member 7
7d99 A 160 A 163
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 160 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9Y666
Residue number A
160
Residue number B
163
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 160 of Solute carrier family 12 member 7
Cysteine 163 of Solute carrier family 12 member 7
7d99 A 163 A 633
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 163 and 633. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9Y666
Residue number A
163
Residue number B
633
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 163 of Solute carrier family 12 member 7
Cysteine 633 of Solute carrier family 12 member 7
7d99 A 161 A 163
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 161 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
nan
Peptide accession
Q9Y666
Residue number A
161
Residue number B
163
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 161 of Solute carrier family 12 member 7
Cysteine 163 of Solute carrier family 12 member 7
7d99 B 160 B 626
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 160 and 626. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9Y666
Residue number A
160
Residue number B
626
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 160 of Solute carrier family 12 member 7
Cysteine 626 of Solute carrier family 12 member 7
7d99 A 588 A 626
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 588 and 626. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9Y666
Residue number A
588
Residue number B
626
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 588 of Solute carrier family 12 member 7
Cysteine 626 of Solute carrier family 12 member 7
7d99 B 163 B 588
A redox-regulated disulphide may form within Solute carrier family 12 member 7 between cysteines 163 and 588. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
25
PDB code
7d99
Structure name
human potassium-chloride co-transporter kcc4
Structure deposition date
2020-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9Y666
Residue number A
163
Residue number B
588
Peptide name
Solute carrier family 12 member 7
Ligandability
Cysteine 163 of Solute carrier family 12 member 7
Cysteine 588 of Solute carrier family 12 member 7
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