ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

28S ribosomal protein S18b, mitochondrial

Intramolecular
Cysteine 94 and cysteine 105
Cysteine 94 and cysteine 108
Cysteine 94 and cysteine 143
Cysteine 105 and cysteine 143
Cysteine 108 and cysteine 143
Cysteine 105 and cysteine 108
A redox-regulated disulphide may form within 28S ribosomal protein S18b, mitochondrial between cysteines 94 and 105.

Details

Redox score ?
84
PDB code
8css
Structure name
human mitochondrial small subunit assembly intermediate (state d)
Structure deposition date
2022-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
5
% buried
nan
Peptide accession
Q9Y676
Residue number A
94
Residue number B
105
Peptide name
28S ribosomal protein S18b, mitochondrial

Ligandability

Cysteine 94 of 28S ribosomal protein S18b, mitochondrial

Cysteine 105 of 28S ribosomal protein S18b, mitochondrial

A redox-regulated disulphide may form within 28S ribosomal protein S18b, mitochondrial between cysteines 94 and 108.

Details

Redox score ?
82
PDB code
8csr
Structure name
human mitochondrial small subunit assembly intermediate (state c)
Structure deposition date
2022-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
5
% buried
68
Peptide accession
Q9Y676
Residue number A
94
Residue number B
108
Peptide name
28S ribosomal protein S18b, mitochondrial

Ligandability

Cysteine 94 of 28S ribosomal protein S18b, mitochondrial

Cysteine 108 of 28S ribosomal protein S18b, mitochondrial

A redox-regulated disulphide may form within 28S ribosomal protein S18b, mitochondrial between cysteines 94 and 143.

Details

Redox score ?
80
PDB code
8css
Structure name
human mitochondrial small subunit assembly intermediate (state d)
Structure deposition date
2022-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
5
% buried
80
Peptide accession
Q9Y676
Residue number A
94
Residue number B
143
Peptide name
28S ribosomal protein S18b, mitochondrial

Ligandability

Cysteine 94 of 28S ribosomal protein S18b, mitochondrial

Cysteine 143 of 28S ribosomal protein S18b, mitochondrial

A redox-regulated disulphide may form within 28S ribosomal protein S18b, mitochondrial between cysteines 105 and 143.

Details

Redox score ?
62
PDB code
8css
Structure name
human mitochondrial small subunit assembly intermediate (state d)
Structure deposition date
2022-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
14
% buried
nan
Peptide accession
Q9Y676
Residue number A
105
Residue number B
143
Peptide name
28S ribosomal protein S18b, mitochondrial

Ligandability

Cysteine 105 of 28S ribosomal protein S18b, mitochondrial

Cysteine 143 of 28S ribosomal protein S18b, mitochondrial

A redox-regulated disulphide may form within 28S ribosomal protein S18b, mitochondrial between cysteines 108 and 143.

Details

Redox score ?
61
PDB code
8csr
Structure name
human mitochondrial small subunit assembly intermediate (state c)
Structure deposition date
2022-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
14
% buried
72
Peptide accession
Q9Y676
Residue number A
108
Residue number B
143
Peptide name
28S ribosomal protein S18b, mitochondrial

Ligandability

Cysteine 108 of 28S ribosomal protein S18b, mitochondrial

Cysteine 143 of 28S ribosomal protein S18b, mitochondrial

A redox-regulated disulphide may form within 28S ribosomal protein S18b, mitochondrial between cysteines 105 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
8css
Structure name
human mitochondrial small subunit assembly intermediate (state d)
Structure deposition date
2022-05-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
22
% buried
nan
Peptide accession
Q9Y676
Residue number A
105
Residue number B
108
Peptide name
28S ribosomal protein S18b, mitochondrial

Ligandability

Cysteine 105 of 28S ribosomal protein S18b, mitochondrial

Cysteine 108 of 28S ribosomal protein S18b, mitochondrial

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