ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ADP-ribosylation factor-like protein 5A

Intramolecular
Cysteine 157 and cysteine 158
Cysteine 132 and cysteine 158
A redox-regulated disulphide may form within ADP-ribosylation factor-like protein 5A between cysteines 157 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2h16
Structure name
structure of human adp-ribosylation factor-like 5 (arl5)
Structure deposition date
2006-05-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y689
Residue number A
157
Residue number B
158
Peptide name
ADP-ribosylation factor-like protein 5A

Ligandability

Cysteine 157 of ADP-ribosylation factor-like protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of ADP-ribosylation factor-like protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ADP-ribosylation factor-like protein 5A between cysteines 132 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2h16
Structure name
structure of human adp-ribosylation factor-like 5 (arl5)
Structure deposition date
2006-05-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y689
Residue number A
132
Residue number B
158
Peptide name
ADP-ribosylation factor-like protein 5A

Ligandability

Cysteine 132 of ADP-ribosylation factor-like protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of ADP-ribosylation factor-like protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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