a tool for identifying drug-targetable redox-active disulphides

Calcium-activated potassium channel subunit beta-2

Intramolecular

Cysteine 227 and cysteine 282

A redox-regulated disulphide may form within Calcium-activated potassium channel subunit beta-2 between cysteines 227 and 282 (263 and 282 respectively in this structure).

Details

Redox score ?

nan

PDB code

Structure name

streptomyces plicatus beta-n-acetylhexosaminidase in complex with (2r, 3r,4s,5r)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidinium chloride (ifg)

Structure deposition date

2001-05-30

Thiol separation (Å)

2

Half-sphere exposure sum ?

61

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

227

Residue number B

282

Peptide name

Calcium-activated potassium channel subunit beta-2

Ligandability

Cysteine 227 of Calcium-activated potassium channel subunit beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Calcium-activated potassium channel subunit beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 in protein B could not be asigned to a Uniprot residue.

If this tool was useful for finding a disulphide, please cite: