ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Voltage-dependent calcium channel gamma-2 subunit

Intramolecular
Cysteine 40 and cysteine 68
Cysteine 40 and cysteine 40
Cysteine 67 and cysteine 77
Cysteine 67 and cysteine 68
Cysteine 68 and cysteine 77
Cysteine 40 and cysteine 67
Cysteine 40 and cysteine 77
Cysteine 63 and cysteine 315
A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-2 subunit between cysteines 40 and 68 (1039 and 1067 respectively in this structure).

Details

Redox score ?
87
PDB code
6dm0
Structure name
open state glua2 in complex with stz and blocked by iem-1460, after micelle signal subtraction
Structure deposition date
2018-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y698
Residue number A
40
Residue number B
68
Peptide name
Voltage-dependent calcium channel gamma-2 subunit

Ligandability

Cysteine 40 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-2 subunit between cysteines 40 and 40 (718 and 773 respectively in this structure).

Details

Redox score ?
86
PDB code
6dlz
Structure name
open state glua2 in complex with stz after micelle signal subtraction
Structure deposition date
2018-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y698
Residue number A
40
Residue number B
40
Peptide name
Voltage-dependent calcium channel gamma-2 subunit

Ligandability

Cysteine 40 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-2 subunit between cysteines 67 and 77 (1066 and 1076 respectively in this structure).

Details

Redox score ?
82
PDB code
5weo
Structure name
activated glua2 complex bound to glutamate, cyclothiazide, and stz in digitonin
Structure deposition date
2017-07-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88602
Residue number A
67
Residue number B
77
Peptide name
Voltage-dependent calcium channel gamma-2 subunit

Ligandability

Cysteine 67 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-2 subunit between cysteines 67 and 68 (1066 and 1067 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6o9g
Structure name
open state glua2 in complex with stz and blocked by agtx-636, after micelle signal subtraction
Structure deposition date
2019-03-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y698
Residue number A
67
Residue number B
68
Peptide name
Voltage-dependent calcium channel gamma-2 subunit

Ligandability

Cysteine 67 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-2 subunit between cysteines 68 and 77 (1067 and 1076 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5weo
Structure name
activated glua2 complex bound to glutamate, cyclothiazide, and stz in digitonin
Structure deposition date
2017-07-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88602
Residue number A
68
Residue number B
77
Peptide name
Voltage-dependent calcium channel gamma-2 subunit

Ligandability

Cysteine 68 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-2 subunit between cysteines 40 and 67 (1039 and 1066 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6o9g
Structure name
open state glua2 in complex with stz and blocked by agtx-636, after micelle signal subtraction
Structure deposition date
2019-03-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y698
Residue number A
40
Residue number B
67
Peptide name
Voltage-dependent calcium channel gamma-2 subunit

Ligandability

Cysteine 40 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-2 subunit between cysteines 40 and 77 (1039 and 1076 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6dm0
Structure name
open state glua2 in complex with stz and blocked by iem-1460, after micelle signal subtraction
Structure deposition date
2018-06-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9Y698
Residue number A
40
Residue number B
77
Peptide name
Voltage-dependent calcium channel gamma-2 subunit

Ligandability

Cysteine 40 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-2 subunit between cysteines 63 and 315.

Details

Redox score ?
nan
PDB code
5kbu
Structure name
cryo-em structure of glua2-2xstz complex at 7
Structure deposition date
2016-06-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O88602
Residue number A
63
Residue number B
315
Peptide name
Voltage-dependent calcium channel gamma-2 subunit

Ligandability

Cysteine 63 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Voltage-dependent calcium channel gamma-2 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 in protein A could not be asigned to a Uniprot residue.
Cysteine 315 in protein B could not be asigned to a Uniprot residue.
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