a tool for identifying drug-targetable redox-active disulphides

EP300-interacting inhibitor of differentiation 1

Intermolecular

Cysteine 846 of Retinoblastoma-like protein 1 and cysteine 180

A redox-regulated disulphide may form between cysteine 846 of Retinoblastoma-like protein 1 and cysteine 180 of EP300-interacting inhibitor of differentiation 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

36

PDB code

Structure name

p107 pocket domain complexed with eid1 peptide

Structure deposition date

2021-10-25

Thiol separation (Å)

10

Half-sphere exposure sum ?

73

Minimum pK_a ?

11

% buried

72

Peptide A name

Retinoblastoma-like protein 1

Peptide B name

EP300-interacting inhibitor of differentiation 1

Peptide A accession

Peptide B accession

Peptide A residue number

846

Peptide B residue number

180

Ligandability

Cysteine 846 of Retinoblastoma-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of EP300-interacting inhibitor of differentiation 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: