ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Testis-specific chromodomain protein Y 2

Intramolecular
Cysteine 343 and cysteine 344
Cysteine 428 and cysteine 514
A redox-regulated disulphide may form within Testis-specific chromodomain protein Y 2 between cysteines 343 and 344 (62 and 63 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2fw2
Structure name
catalytic domain of cdy
Structure deposition date
2006-01-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
88
Peptide accession
Q9Y6F7
Residue number A
343
Residue number B
344
Peptide name
Testis-specific chromodomain protein Y 2

Ligandability

Cysteine 343 of Testis-specific chromodomain protein Y 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 344 of Testis-specific chromodomain protein Y 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Testis-specific chromodomain protein Y 2 between cysteines 428 and 514 (147 and 233 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2fw2
Structure name
catalytic domain of cdy
Structure deposition date
2006-01-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Y6F7
Residue number A
428
Residue number B
514
Peptide name
Testis-specific chromodomain protein Y 2

Ligandability

Cysteine 428 of Testis-specific chromodomain protein Y 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 514 of Testis-specific chromodomain protein Y 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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