ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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39S ribosomal protein L42, mitochondrial

Intermolecular
Cysteine 93 of 39S ribosomal protein L20, mitochondrial and cysteine 60
Intramolecular
Cysteine 45 and cysteine 60 L
A redox-regulated disulphide may form between cysteine 93 of 39S ribosomal protein L20, mitochondrial and cysteine 60 of 39S ribosomal protein L42, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
5ool
Structure name
structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rrna
Structure deposition date
2017-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
100
Peptide A name
39S ribosomal protein L20, mitochondrial
Peptide B name
39S ribosomal protein L42, mitochondrial
Peptide A accession
Q9BYC9
Peptide B accession
Q9Y6G3
Peptide A residue number
93
Peptide B residue number
60

Ligandability

Cysteine 93 of 39S ribosomal protein L20, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of 39S ribosomal protein L42, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein L42, mitochondrial between cysteines 45 and 60. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7oib
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 3d
Structure deposition date
2021-05-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
96
Peptide accession
Q9Y6G3
Residue number A
45
Residue number B
60
Peptide name
39S ribosomal protein L42, mitochondrial

Ligandability

Cysteine 45 of 39S ribosomal protein L42, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 60 of 39S ribosomal protein L42, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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